5-羟色胺与Toll样受体及肠道菌群之间关系的研究  

Research in relationship among 5-hydroxytryptamine,Toll-like receptors and intestinal microbiota

作　　者：唐艳[1] 刘志洲[2] 邓英[1] 董为为 朱学良 李明[1] 袁杰利[1] 

机构地区：[1]大连医科大学微生态学教研室,辽宁大连116044 [2]解放军210医院403临床部,辽宁大连116021 [3]武汉百信正源生物技术工程有限公司,湖北武汉430010

出　　处：《中国微生态学杂志》2016年第12期1470-1473,共4页Chinese Journal of Microecology

基　　金：辽宁省自然科学基金(2015020262);国家"863"计划(2014AA022200)

摘　　要：5-羟色胺(5-HT)是参与调节胃肠道运动、内脏敏感性、分泌等功能的重要神经递质和信号分子。肠道菌群对5-HT的产生有重要影响,已发现一些产芽孢细菌(spore-forming bacteria,SP)类肠道微生物能刺激肠嗜铬细胞(enterochromaffin cell,EC)产生5-HT。微生物通过Toll样受体(Toll-like receptors,TLR)激活神经分泌机制来调节胃肠运动,某些TLR通过作用于5-HT受体调节小鼠回肠的自主收缩和5-HT诱导的收缩反应。通过调节肠道菌群可以对5-HT综合征及其相关生理和病理状况产生重要影响。因此,对5-HT与TLR及肠道菌群相互之间的关系进行进一步的研究有重要意义。5-hydroxytryptamine （5-HT） is an important neurotransmitter and signaling molecule which involved in regulating gastrointestinal movement, visceral sensitivity and secretion function. Recent study have found some spore-forming bacteria （SP） gut microbes can stimulate the enterochromaffin cell （EC） to produce 5-HT. Microorganisms regulate gastrointestinal movement through Toll-like receptor （TLR） activated neurosecretory mechanism. Some TLRs can act on 5 HT receptor to regulate autonomic contraction in mice. The intestinal microbiota likely has important influence on 5-HT syndrome and is related with physiological and pathological conditions. Therefore, further research about the relationship among 5-HT, TLR and intestinal microbiota is valuable.

关 键 词：肠道菌群 5-羟色胺 TOLL样受体 5-羟色胺综合征 

分 类 号：R574[医药卫生—消化系统]