间隙连接蛋白Cx43在肿瘤发生发展中作用  

Role of Connexin 43 in the Genesis and Development of Tumor

作　　者：张彩霞[1] 江滨[2] 张亚杰[2] 方明治[2] 

机构地区：[1]南京中医药大学,江苏南京210009 [2]南京中医药大学第三附属医院,南京市中医院,江苏南京210001

出　　处：《辽宁中医药大学学报》2017年第1期147-151,共5页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：江苏省“六大人才高峰”第十二批高层次人才选拔培养计划项目(WSW069);江苏省第四期“333工程”科研项目(24);南京市医学科技发展项目(南京市卫生局重点资助项目)(ZKX15040)

摘　　要：近年来,世界范围内肿瘤的发病率及其增长速度逐年提升,细胞间隙连接通讯在肿瘤的发生、侵袭和转移中具有极其重要的作用,其通讯功能的正常与否与间隙连接蛋白Cx43的表达水平直接相关,以Cx43为靶点,通过提高Cx43表达水平来实现抑制肿瘤发生、侵袭和转移的中药提取物、中药方剂、生物制剂已有零星报道。药物是通过何种机制调节细胞Cx43的生成、转运和激活其功能,尚不明确,该文对于间隙连接蛋白Cx43在肿瘤发生发展中的作用做一综述。In recent years,the incidence of cancer and its growth rate in the world increased year by year,gap junction intercellular communication plays an extremely important role in the occurrence,invasion and metastasis of tumor,its communication function is directly related to the expression of Cx43,some traditional Chinese medicine extract,traditional Chinese medicine prescription and biological agents who regard Cx43 as the target and realize the inhibition of the occurrence,invasion and metastasis of tumor through improving the expression of Cx43 have been reported. The mechanisms to regulate the generation,transport and activation of Cx43 by drugs are still not clear. This article reviews the role of Cx43 in the development of cancer.

关 键 词：肿瘤 细胞间隙连接通讯 连接蛋白CX43 

分 类 号：R73[医药卫生—肿瘤]