他汀类药物对伴糖尿病牙周炎患者龈沟液基质金属蛋白酶的影响  

Effect of Statins on Matrix Metalloproteinases in Patients with Diabetes Mellitus and Periodontitis

作　　者：侯佳[1] 陶洪[1] 

机构地区：[1]西安交通大学第一附属医院口腔科,710061

出　　处：《医学研究杂志》2017年第1期124-126,131,共4页Journal of Medical Research

摘　　要：目的探究他汀类药物对伴糖尿病牙周炎患者龈沟液基质金属蛋白酶变化影响。方法选取糖尿病使用他汀类药物治疗患者(ST组)、糖尿病未使用他汀类药物治疗者(NST组)、非糖尿病牙周炎患者(牙周炎组)及牙周正常者(对照组)各30例,ELISA法测量出血指数(BI)、菌斑指数(PLI)、附着丧失(AL)、龈沟液量(GCF)、基质金属蛋白酶及基质金属蛋白酶组织抑制因子1水平,并对比糖化血红蛋白(Hb A1c)、随机血糖(RPG)间差异。结果糖尿病患者AL、BI、GCF明显增高(P<0.05);与NST组相比,ST组AL、BI、GCF明显降低(P<0.05)。牙周炎患者MMP-1、MMP-1/TIMP-1均明显高于对照组(P<0.05),NST组MMP-1、MMP-1/TIMP-1明显高于牙周炎组(P<0.05)。ST组Hb A1c、MMP-1、MMP-1/TIMP-1明显低于NST组(P<0.05)。但两组MMP-8间差异无统计学意义(P>0.05)。结论他汀类药物能降低伴糖尿病牙周炎患者龈沟液MMP-1、MMP-1/TIMP-1水平,对降低血糖并且改善患者牙周病理生理状况具有潜在价值。Objective To explore the effect of statins on the changes of matrix metalloproteinases in patients with diabetes mellitus and periodontitis. Methods We chosen statin therapy in patients with diabetes （ST group） of patients with diabetes,diabetes patients without statin treated （NST group）, non diabetes periodontitis patients （periodontitis group） and periodontal normal patients （control group）, each group of 30 cases. We measured the bleeding index （BI）, plaque index （PLI）, attachment loss （AL） and gingival crevic- ular fluid volume （GCF） , level of matrix metalloproteinase and tissue inhibitor of metalloproteinase - 1 （ TIMP - 1 ） and the contrast of glycosylated hemoglobin （ HbA1 c）, random blood glucose （RPG） differences with ELISA method. Results AL, BI and GCF were signif- icantly higher in diabetic patients（P 〈 0.05 ）. Compared with NST group, AL, BI and GCF in ST group were significantly decreased（ P 〈 0. 05）. The levels of MMP - 1 and MMP - 1/TIMP - 1 in patients with periodontitis were significantly higher than those in the control group（P 〈0.05） , MMP - 1/TIMP - 1 and MMP - 1 were significantly higher in the NST group than the control group（P 〈0.05）. The levels of HbAlc, MMP - 1, MMP - 1/TIMP - 1 in ST group were significantly lower in NST group（ P 〈 0. 05 ）. But the difference of MMP - 8 between the two groups was not statistically significant（P 〉 0. 05）. Conclusion Statins can decrease the levels of MMP - 1 and MMP - 1/TIMP - 1 in the patients with diabetes mellitus and periodontitis, and have potential value in reducing blood glucose and improving the physiological condition of the patients＇ periodontal condition.

关 键 词：他汀类药物 糖尿病 牙周炎 MMP-1 MMP-8 TIMP-1 MMP-1 MMP-8 TIMP-1 

分 类 号：R78[医药卫生—口腔医学]