前列地尔、硫辛酸联合西洛他唑治疗糖尿病周围神经病变疗效观察  

Efficacy of Alprostadil and Lipoic Acid Combined with Cilostazol in Treatment of Diabetic Peripheral Neuropathy

作　　者：张瑶[1] 胡军[1] 许腾[1] 金肆[1] 朱琳[1] 杨少娟[1] 高啸[1] 廖丹[1] 江燕丽 ZHANG Yao HU Jun XU Teng JIN Si ZHU Lin YANG Shao-juan GAO Xiao LIAO Dan JIANG Yan-li(Department of Endocrinology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430077, Chin)

机构地区：[1]华中科技大学同济医学院附属梨园医院内分泌科,武汉430077

出　　处：《神经损伤与功能重建》2016年第6期500-503,共4页Neural Injury and Functional Reconstruction

摘　　要：目的:观察前列地尔、硫辛酸和西洛他唑3药联合使用对糖尿病周围神经病变(DPN)的疗效。方法:DPN患者76例,随机分为对照组和治疗组各38例,在糖尿病基础治疗基础上,对照组给予前列地尔和硫辛酸治疗,治疗组给予前列地尔、硫辛酸和西洛他唑3药联用。于治疗前和治疗4周后,检测并分析2组运动神经传导速度(MCV)、感觉神经传导速度(SCV)、运动神经复合肌动作电位(CMAP)波幅、CMAP潜伏期和感觉神经动作电位(SNAP)波幅的变化和神经病变主觉症状问卷(TSS)评分。结果:治疗前,2组TSS评分、神经传导速度、CMAP波幅、CMAP潜伏期和SNAP波幅无统计学差异(P>0.05);治疗后,2组TSS评分和CMAP潜伏期均低于治疗前,且治疗组低于对照组(P<0.01);2组MCV、CMAP波幅、SNAP波幅和SCV均较治疗前提高(P<0.01),且治疗组优于对照组(P<0.05)。结论:前列地尔、硫辛酸和西洛他唑3药联用治疗DPN疗效好于前列地尔、硫辛酸2药联用。Objective： To explore the effects of alprostadil and lipoic acid combined with cilostazol on treatment of diabetic peripheral neuropathy（DPN）. Methods： Seventy-six patients with DPN were randomly divided into two groups（n=38 each）. Cases in the control group were treated with alprostadil and lipoic acid, while those in the experimental group were treated with alprostadil, lipoic acid and cilostazol for 4 weeks. The alterations of motor nerve conduction velocity（MCV）, sensory nerve conduction velocity（SCV）, compound muscle action potential（CMAP） amplitude, CMAP latency, sensory nerve action potential（SNAP） amplitude, and total symptoms scores（TSS） were detected in all patients before and after treatment. Results： Before the treatment,the TSS score and CMAP latency were comparable between the two groups（P〉0.05）. After the treatment, the TSS score and CMAP latency were decreased in the both groups, but the degree of decline was greater in the experimental group than that in the control group（P〈0.01）. The SCV, CMAP amplitude, SNAP amplitude and MCV were improved in the both groups after the treatment（P〈0.01）, but the improvement was more significant in the experimental group than those in the control group（P〈0.05）. Conclusion： The treatment of alprostadil and lipoic acid combined with cilostazol has better effect on DPN.

关 键 词：前列地尔 西洛他唑 硫辛酸 糖尿病周围神经病变 

分 类 号：R741[医药卫生—神经病学与精神病学] R745[医药卫生—临床医学]