经颅直流电刺激治疗阿尔茨海默氏病临床疗效观察  

Clinical Efficacy of Transcranial Direct Current Stimulation on Treatment of Alzheimer's Disease

作　　者：王东 贾颐 卢春晖 WANG Dong JIA Yi LU Chun-hui(Department of Neurology, Traditional Chinese Medicine, Shanxi 714000, China Department of Neurology, Xi ＇an Gaoxin Hospital, Xi ＇an 710065, China Department of Internal Medicine, Changqing Xinglongyuan Hospital of Xi ＇an city, Xi ＇an 710018, China)

机构地区：[1]渭南市中医医院神经内科,陕西渭南714000 [2]西安高新医院神经内科,西安710065 [3]西安市长庆兴隆园医院内科,西安710018

出　　处：《神经损伤与功能重建》2016年第6期509-511,共3页Neural Injury and Functional Reconstruction

摘　　要：目的:探讨经颅直流电刺激(t DCS)治疗阿尔茨海默氏病(AD)的临床疗效。方法:AD患者120例随机分为对照组和t DCS组各60例,对照组给予假电流治疗,t DCS组给予t DCS治疗,连续治疗5个疗程,比较2组治疗前及治疗后、治疗后1月和2月简易智力状态检查量表(MMSE)和韦氏成人智能量表评分以及治疗前后事件相关电位(P300)的潜伏期、波幅和反应时间。结果:t DCS组治疗后的MMSE评分高于治疗前,且持续上升(P<0.05);治疗后、治疗后1月和治疗后2月的MMSE评分高于对照组(P<0.05);t DCS组治疗后的词汇表、信息以及数字广度评分高于治疗前(P<0.05),治疗后、治疗后1月和治疗后2月词汇表、信息以及数字广度评分高于对照组(P<0.05);t DCS组治疗后的P300电位潜伏期低于治疗前(P<0.05)和对照组(P<0.05)。结论:t DCS治疗显著改善AD患者的认知功能,降低其P300潜伏期。Objective： To investigate the clinical efficacy of transcranial direct current stimulation（t DCS） on treatment of Alzheimer＇s disease（AD）. Methods： One hundred and twenty AD patients were randomly divided into control groups and t DCS groups with 60 cases in each group. The control group were treated with false current stimulation, and the t DCS group were treated with t DCS for 5 courses. The Mini-Mental State Examination（MMSE） and the Wechsler Adult Intelligent Scale scores between the two groups before and after treatment 1-month and 2-month were compared. The event-related potentials（P300） in latency, amplitude and reaction time in the two groups were also compared. Results： The MMSE score in the t DCS group increased continuously and was significantly higher than that before treatment（P〈0.05）.The MMSE scores in the t DCS group were significantly higher than that in the control group after 1-month and 2-month treatment（P〈0.05）. Vocabulary, information and digital data breadth scores in the t DCS group were significantly higher than that before treatment（P〈0.05）, and also higher than that in control group after 1-month and 2-month treatment（P〈0.05）. The P300 potential latency after treatment of the t DCS group was significantly lower than that before treatment（P〈0.05）, and was lower than that in the control group（P〈0.05）. Conclusion： Cortical direct current stimulation therapy could significantly improve the Alzheimer＇s cognitive function, and reduce P300 latency.

关 键 词：经颅直流电刺激 阿尔茨海默氏病 韦氏成人智能量表 听觉事件相关电位P300 

分 类 号：R741[医药卫生—神经病学与精神病学] R741.05[医药卫生—临床医学]