抽动障碍儿童血清S100β、CK-BB及GFAP的变化及预后的影响因素分析  

Changes of Serum S100β,CK-BB and GFAP levels in Children with Tic Disorder and Analysis of Risk Factors for Poor Prognosis

作　　者：秋艳萍[1] 焦爱萍[1] 张孝兴[1] 席聪[2] QIU Yan-ping JIAO Ai-ping ZHANG Xiao-xing XI Cong(Baoji Maternity ＆ Child Healthcare Hospital, Shanxi 721000, China Department of Neurology, Shanxi Baoji People＇s Hospital, Shanxi 721000, China)

机构地区：[1]宝鸡市妇幼保健院儿科,陕西宝鸡721000 [2]宝鸡市人民医院神经内科,陕西宝鸡721000

出　　处：《神经损伤与功能重建》2016年第6期529-532,共4页Neural Injury and Functional Reconstruction

摘　　要：目的:探讨抽动障碍儿童血清S100β蛋白、肌酸激酶脑型同工酶(CK-BB)及胶质纤维酸性蛋白(GFAP)水平变化及影响其预后的危险因素。方法:抽动障碍患儿106例根据耶鲁综合抽动严重程度量表(YGTSS)分为中度组83例和重度组23例,选取健康儿童20例为对照组。所有患儿给予硫必利治疗12周。于治疗前、后采血测量血清S100β、CK-BB及GFAP水平,采用多因素logistic回归分析法分析影响患儿预后的危险因素。结果:治疗前,中、重度组的血清S100β、CK-BB及GFAP的浓度均显著高于健康组(均P<0.05),且重度组血清S100β和GFAP均高于中度组(均P<0.05)。治疗后,中、重度组所有指标均低于治疗前(均P<0.05),且中度组血清S100β水平低于重度组(均P<0.05)。根据YGTSS评分,预后良好组共84例,预后不良组22例。2组病情严重程度、病情反复频数及治疗前血清GFAP水平3项指标差异具有统计学意义(均P<0.05),且均是发生抽动障碍患儿预后不佳的危险因素(均P<0.05)。结论:抽动障碍患儿血清中3种脑损伤的参数S100β、CK-BB及GFAP均明显升高,GFAP是该疾病预后不良的危险因素之一。Objective： To analyze the risk factors for poor prognosis in children with tic disorder（TD） and observe the changes in serum S100β, creatine kinase（CK）- BB and glial fibrillary acidic protein（GFAP） expression. Methods： According to Yale Global Tic Severity Scale（YGTSS）, 106 children with TD were divided into moderate group（83 cases） and severe group（23 cases）. Twenty healthy children were selected control group. All children with TD received the treatment of Tiapride for 12 weeks. At the first visit after 12-week treatment, the levels of serum S100β, CK-BB and GFAP were detected. Multi-factor logistic regression method was used to analyze the risk factors for poor prognosis. Results： The levels of serum S100β, CK-BB and GFAP in the moderate group and severe group were significantly higher than those in the control group（P〈0.05）. Meanwhile, these levels in the severe group were significantly higher than those in the moderate group（P〈0.05）. After 12- week treatment, the levels of serum S100β, CK-BB and GFAP in children with TD were significantly lower than those before the treatment（P〈0.05）. For the children with TD, severity of TD, the times of reputation and the level of serum GFAP were risk factors for poor prognosis（P〈0.05）. Conclusion： The levels of serum S100β, CK-BB and GFAP in children with TD were higher than those in healthy children and GFAP was the risk factor for poor prognosis.

关 键 词：抽动障碍 S100Β蛋白 肌酸激酶脑型同工酶-BB 胶质纤维酸性蛋白 危险因素 

分 类 号：R741[医药卫生—神经病学与精神病学] R746[医药卫生—临床医学]