宫颈癌新辅助化疗前后SCC-Ag水平与化疗敏感性的关系  

The relationship between SCC-Ag level and chemotherapy sensitivity in cervical cancer before and after neoadjuvant chemotherapy

作　　者：程金龙[1] 徐冶[1] 谢宏宇[2] 娄阁[1] Cheng Jinlong Xu Ye Xie Hongyu Lou Ge(Department of Gynecology and Oncology, The Affiliated Tumor Hospital of Harbin Medical University,Heilongjiang Harbin 150081, China Department of Medical Statistics ,Harbin Medical University , Heilongjiang Harbin 150081, China.)

机构地区：[1]哈尔滨医科大学附属肿瘤医院妇一科,黑龙江哈尔滨150081 [2]哈尔滨医科大学卫生统计学教研室,黑龙江哈尔滨150081

出　　处：《现代肿瘤医学》2016年第23期3790-3793,共4页Journal of Modern Oncology

基　　金：国家自然科学基金(编号:81472028)

摘　　要：目的:探究化疗前,化疗后SCC-Ag对宫颈癌新辅助化疗(NACT)敏感性的预测价值。方法:收集262例宫颈鳞癌患者的完整信息,研究SCC-Ag与各临床特征的关系,并分析影响宫颈癌NACT敏感性的因素,重点探讨不同阶段SCC-Ag对化疗敏感性的评估作用。结果:宫颈鳞癌患者NACT前SCC-Ag水平与年龄、绝经情况及组织分型无关(P>0.05),与肿瘤直径、FIGO分期和淋巴结转移呈正相关。NACT有效率为71.0%(186/262),影响其敏感性的因素有肿瘤直径和FIGO分期。按NACT后SCC-Ag下降的百分比分为<0.40、[0.40,0.70)、≥0.70三组,各组所对应的肿瘤直径的变化分别为(6.18±10.07)mm、(21.30±11.93)mm、(28.47±14.27)mm,而这三组所对应的化疗反应率分别为14.52%、80.46%、94.69%,以上结果均具有统计学意义(P<0.05)。结论:化疗后下降的SCC-Ag对宫颈癌NACT敏感性具有很好的评估价值。Objective： To explore the predictive value for sensitivity of neoadjuvant chemotherapy with squamous cell carcinoma antigen in cervical cancer pre- chemotherapy,post- chemotherapy. Methods： Collecting complete information of 262 patients with squamous cell carcinoma of the uterine cervix,studied the relationship between SCC-Ag and clinical features and analyzed the factors of the sensitivity in NACT for cervical cancer,focusing on different stages of SCC- Ag for evaluating the sensitivity of chemotherapy. Results： The pre- therapy SCC- Ag had no relation with age,menopause and histological classification（ P〉0. 05）,but positively correlated with tumor size,FIGO stage and lymph node metastasis. The effective rate was 71. 0%（ 186 /262）,the factors of sensitivity were tumor size and FIGO stage. According to the percentage of SCC- Ag decreasing after NACT,patients were divided into three groups including〈0. 40,[0. 40,0. 70）,≥0. 70,changes of tumor size in each group was（ 6. 18 ± 10. 07） mm,（ 21. 30 ±11. 93） mm,（ 28. 47 ± 14. 27） mm respectively,and the response rates of the three groups were 14. 52%,80. 46%,94. 69% respectively,all these results had statistical significance（ P〈0. 05）. Conclusion： The SCC- Ag level decreased after the chemotherapy has good value on evaluating the sensitivity of NACT in cervical cancer.

关 键 词：宫颈癌 新辅助化疗 敏感性 鳞状细胞癌抗原 

分 类 号：R737.33[医药卫生—肿瘤]