中枢神经系统ERK信号通路在药物成瘾中的作用机制研究进展  

Research Progress on mechanism of ERK signaling pathway in drug addiction

作　　者：张盼盼[1] 徐文锦[1] 刘惠芬[2] 

机构地区：[1]宁波大学医学院,浙江宁波315211 [2]宁波市微循环与莨菪类药研究所,宁波大学行为神经科学研究中心,浙江宁波315010

出　　处：《中国药理学通报》2017年第1期1-9,共9页Chinese Pharmacological Bulletin

基　　金：浙江省自然科学基金面上项目资助项目(No LY14H310002);宁波市科技计划项目(No 2013C50033,2015C110026);国家重点基础研究发展计划资助项目(No 2015CB553504)

摘　　要：药物成瘾是一种慢性复发性脑病。反复的药物暴露可引起脑环路产生神经适应性变化,导致强迫性觅药行为以及复吸。有许多研究发现,生物体内细胞间的信号转导级联放大通路介导的中枢神经系统奖赏环路的重塑,以及成瘾相关的学习和记忆的神经可塑性改变是药物成瘾的重要分子机制。研究表明细胞外调节激酶(extracellular signal-regulatedkinase,ERK)与药物成瘾引起的神经适应性、奖赏效应和觅药行为的复吸直接相关。因此,该文就ERK在药物成瘾中的作用机制做系统的综述。药物成瘾中ERK信号通路作用机制的研究将为深入理解药物成瘾的分子调控机制提供重要的理论基础,并为临床药物成瘾和复吸的治疗提供新的分子靶标和新的策略。Drug addiction is a chronic relapsing brain disease.Repeated drug exposure can cause neuroadaptations in major brain circuitries,leading to compulsive drug consumption behavior and relapse after abstinence. Many studies have found that intercellular signaling cascades mediated central nervous system remodeling in the rewarding circuitry and addiction associated neuroplasticity of learning and memory are important molecular mechanism of drug addiction. Studies show that extracellular signal-regulated kinase（ ERK） is associated with drug-mediated psychomotor activity,rewarding properties and relapse of drug seeking behaviors. Therefore,this article has reviewed the role of ERK signaling pathway in drug addiction. Research on the role of ERK signaling pathway in drug addiction will provide important theoretical foundation for in-depth understanding of the molecular mechanism of drug addiction and shine a light on new molecular targets and treatment strategies for drug addiction.

关 键 词：药物成瘾 神经可塑性 奖赏效应 觅药行为 复吸 ERK 

分 类 号：R-05[医药卫生] R338.64