小肠间质瘤术后复发影响因素分析:基于单中心数据的研究  

Analysis of recurrence factors of small intestine gastrointestinal stromal tumor after tumor resection based on single clinical center

作　　者：桑江勇 高晓东[2] 薛安慰 方勇[2] 束平[2] 凌佳倩 侯英勇[3] 沈坤堂[2] 秦净[2] 孙益红[2] 秦新裕[2] SAN G Jiang-yong GAO Xiao-dong X U E An-wei FA N G Yong SH U Ping LIN G Jia-qian HOU Ying-yong SH EN Kun-tang QIN Jing SUN Yi-hong QIN Xin-yu(Department of General Surgery, Kashi No. 2 Hospital of the Xinjiang Uygur Autonomous Region, Kashi 8 4 4 0 0 0 , XinjiangUygur Autonomous Region, China Department of General Surgery, Zhongshan H ospital, Fudan University, Shanghai 200032, China Department of Pathology, Zhongshan H ospital, Fudan University, Shanghai 200032, China)

机构地区：[1]新疆维吾尔自治区喀什地区第二人民医院普通外科,喀什844000 [2]复旦大学附属中山医院普通外科,上海200032 [3]复旦大学附属中山医院病理科,上海200032

出　　处：《中国临床医学》2016年第6期773-775,共3页Chinese Journal of Clinical Medicine

基　　金：上海市科学技术委员会基金(14140902302)~~

摘　　要：目的:探讨影响小肠间质瘤(gastrointestinal stromal tumor,GIST)复发的高危因素。方法:回顾性分析2004年1月至2013年12月复旦大学附属中山医院收治的67例小肠GIST复发患者的临床资料。采用Kaplan-Meier法分析不同因素对小肠GIST复发时间的影响;采用Cox多因素回归分析法分析小肠GIST复发的独立影响因素。结果:单因素分析发现:肿瘤直径>10cm、核分裂象≥30个/50HPF(高倍视野)、肿瘤破裂以及R0切除患者的中位复发时间明显缩短,差异有统计学意义(P<0.05);多因素分析发现:肿瘤破裂、手术方式是小肠GIST复发的独立影响因素(P<0.05)。结论:R0切除、术中避免肿瘤破裂可延长小肠GIST的复发时间。Objective ： T o investigate the recurrence factors of small intestine gastrointestinal stromal tumor （G IS T ）after resection Methods： T h e clinicopathological data of 67 patients with recurrent small intestine G IS T admitted to ZhongshanHospital affiliated to Fudan University from January 2004 to December 2013 were retrospectively analyzed. Kaplan-Meiermethod was used to analyze the effects of different factors on the recurrence time of small intestine G IST. Cox multi-factorregression analysis was used to analyze the independent factors of recurrence of small intestine G IST. Results ： Univariateanalysis revealed that the median recurrence time significantly shortened in patients with tumor diameter more than 10 cm,mitotic rate greater than or equal to 30/50 H P F , tumor rupture, and R 〇 resection, and the difference was significant （P〈C0. 0 5 ）. Multivariate analysis demonstrated that tumor rupture and surgical methods were independent prognostic factors for therecurrence of small intestine G IS T （P 〈 C 0 . 0 5 ）. Conclusions： R 0 resection and intraoperative tumor rupture avoidance canprolong the recurrence time of small intestine G IST .

关 键 词：胃肠间质瘤 手术 预后 

分 类 号：R735.3[医药卫生—肿瘤]