阿加曲班治疗急性脑梗死的疗效及对血清和肽素(CPP)、N末端脑钠肽前体的影响  

The influence of CPP and NT-pro BNP and the treatment effect of acute cerebral infarction treated by argatroban

作　　者：余利生[1] 罗凌云[1] 

机构地区：[1]中山大学附属第三医院粤东医院神经内科,广东梅州510000

出　　处：《吉林医学》2017年第1期20-22,共3页Jilin Medical Journal

摘　　要：目的:分析阿加曲班治疗急性脑梗死疗效以及对患者血清和肽素(CPP)、N末端脑钠肽前体(NT-pro BNP)指标的影响。方法:选择90例急性脑梗死患者,随机分为两组。45例为对照组,应用吸氧、卧床以及肠内营养等治疗;45例为观察组,在对照组基础上给予阿加曲班治疗。比较患者治疗效果及相关临床指标。结果:治疗后,患者血清中CPP与NT-pro BNP水平明显降低,且观察组比对照组更低,差异有统计学意义(P<0.05);治疗后,患者汉密顿抑郁量表(HAMD)、神经功能缺损程度量表(CSS)评分及日常生活能力(Barthel)指数改善显著,且观察组优于对照组,差异有统计学意义(P<0.05);观察组疗效高于对照组,差异有统计学意义(P<0.05)。结论:阿加曲班可以降低急性脑梗死患者血清中CPP、NT-pro BNP水平,改善神经功能,疗效显著。Objective The analysis of influence of CPP and NT-pro BNP and the treatment effect of acute cerebral infarction treated by argatroban. Method 90 cases of patients with acute cerebral infarction were selected,they were randomly divided into two groups. The 45 cases as the control group,they were treated by oxygen uptake,lie in bed and enteral nutrition. The 45 cases as the treatment group,they treated by argatroban based on the control. To compare the treatment effect and other clinical tar-gets. Results After treatment,the level of CPP and NT-proB NP in the serum was significantly decreased,and the treatment group was lower than the control,the difference was statistically significante（ P〈0. 05）. After treatment,the grade of HAMD and CSS,and level of Barthel was significantly improved,the treatment group was better than the control,the difference was statistically significant（ P〈0. 05）. Conclusion The argatroban able to reduce the level of CPP and NT-proB NP in the serum of the patients,improve the neurological function,and effective in treatment.

关 键 词：阿加曲班 急性脑梗死 CPP NT-pro BNP 

分 类 号：R743.33[医药卫生—神经病学与精神病学]