肝硬化并自发性腹膜炎与NOD2相关性的研究进展  

Progress of the relationship between spontaneous bacterial peritonitis in hepatic cirrhosis and NOD2

作　　者：焦正红 王拱辰[1,2] 

机构地区：[1]遵义医学院,贵州遵义534100 [2]大连市第六人民医院肝病十科

出　　处：《胃肠病学和肝病学杂志》2017年第1期10-13,共4页Chinese Journal of Gastroenterology and Hepatology

基　　金：大连市卫计委科研基金(201649)

摘　　要：自发性腹膜炎(spontaneous bacterial peritonitis,SBP)被定义为没有可识别的腹腔内外科性感染源的腹水细菌性感染。SBP是失代偿期肝硬化的一个主要的并发症,SBP的诊断为腹腔穿刺腹水中性粒细胞计数的升高(≥250个/mm3)和/或腹水培养阳性。核苷酸结合寡聚化结构域蛋白2(NOD2)是NOD样受体家族的成员,是天然免疫反应的关键。本文就近几年肝硬化并SBP与NOD2相关性研究进展作一概述。Spontaneous bacterial peritonitis（SBP） is defined as acute infection of ascitic fluid without any identifiable surgically treatable intra-abdominal source. SBP is a major complication of decompensated cirrhosis with ascites.SBP is diagnosed by abdominal paracentesis with an elevated ascitic fluid neutrophil count（≥ 250 cells/mm3） and/or a positive ascitic flid culture. Nucleotide-binding oligomerization domain-containing protein 2（NOD2）,a member of the nod-like receptors family,are crucial for innate immune responses. The purpose of this article reviewed the research progress of the relationship between spontaneous bacterial peritonitis in hepatic cirrhosis and NOD2 in recent years.

关 键 词：肝硬化 自发性腹膜炎 核苷酸结合寡聚化结构域蛋白2 

分 类 号：R575.2[医药卫生—消化系统]