血清Cys C在亚临床肝肾综合征中的诊断价值  

The value of serum Cys C in diagnosis of subclinical hepatorenal syndrome

作　　者：张利利[1] 李莉[1] 纪桂贤[1] 郝礼森 高福来[1] 谢长顺[1] 崔红梅[1] 杨梅[1] 

机构地区：[1]秦皇岛市第一医院消化内科,河北秦皇岛066000 [2]华北理工大学附属医院消化科

出　　处：《胃肠病学和肝病学杂志》2017年第1期25-28,共4页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的探讨肾功能正常肝硬化患者血清胱抑素C(Cys C)在亚临床肝肾综合征(hepatorenal syndrome,HRS)诊断中的价值。方法选取2011年8月-2013年8月秦皇岛市第一医院住院的肝硬化患者90例,根据病因分组,采用生化仪检测血清Cys C、尿素氮(BUN)、血肌酐(SCr),彩色多普勒测量肾主动脉内径及肾动脉主干收缩期最大流速(PSV)、舒张末期血流速度(EDV),并计算出肾动脉阻力指数(RI),分析不同组患者血清Cys C与肾动脉RI相关性。结果肝硬化腹水组与肝硬化无腹水组、对照组比较,血清Cys C、肾动脉RI明显升高(P<0.05);肝硬化无腹水组与对照组比较,Cys C、肾动脉RI轻度升高,但差异无统计学意义(P>0.05)。不同病因肝硬化腹水患者血清Cys C及肾动脉血流动力学指标差异均无统计学意义(P>0.05)。肝硬化腹水患者血清Cys C与肾动脉RI呈正相关(P<0.05)。结论血清Cys C可及早识别亚临床HRS,为HRS的早期预防和治疗提供依据。Objective To investigate clinical value of serum Cys C in diagnosis of subclinical hepatorenal syndrome.Methods From Aug. 2011 to Aug. 2013,90 cirrhosis patients in the First Hospital of Qinhuangdao were chosen for the study. According to the clinical manifestations and causes grouping,serum Cys C,BUN and SCr were detected by biochemical analyzer,renal aorta inner diameter,renal artery trunk PSV,EDV were detected by Color Doppler,the renal artery RI,serum Cys C and renal artery RI correlation of different groups were analyzed. Results Compared with cirrhosis without ascites group and the control group,serum Cys C and renal artery RI were significantly increased in cirrhosis ascites group（P〈0. 05）. Compared with control group,serum Cys C and renal artery RI were slightly increased in cirrhosis without ascites group,but had no significant difference（P〉0. 05）. Among different causes of cirrhosis ascites patients,serum Cys C and renal artery RI had no significant difference（P〉0. 05）. Serum Cys C and renal artery RI were positively correlated in cirrhosis. Conclusion Serum Cys C can identify subclinical HRS,provide the basis for the early prevention and treatment of HRS.

关 键 词：亚临床肝肾综合征 血清CYS C 肝硬化 肾血流动力学 

分 类 号：R575.2[医药卫生—消化系统]