受体IL-28B基因多态性对肝移植术后丙型肝炎复发抗病毒治疗及预后的影响  

Influence of recipient IL-28B polymorphisms in recurrent hepatitis C patients after liver transplantation on the antiviral therapy and prognosis

作　　者：周双男[1] 张宁[2] 刘振文[1] 李洪苓[1] 王琳[1] 苏海滨[1] 高银杰[1] 周霞[1] 张敏[1] 

机构地区：[1]解放军第302医院肝移植中心,北京100039 [2]解放军第302医院中西医结合肝病中心,北京100039

出　　处：《胃肠病学和肝病学杂志》2017年第1期74-77,共4页Chinese Journal of Gastroenterology and Hepatology

基　　金：2013年解放军第302医院院长创新基金(YNKT2013021);2014年解放军第302医院院长创新基金(YNKT2014021)

摘　　要：目的探讨受体白介素28B(interleukin-28B,IL-28B)基因多态性对肝移植术后丙型肝炎复发抗病毒治疗及预后的影响。方法对33例肝移植术后丙型肝炎复发患者进行干扰素联合利巴韦林抗病毒治疗,并通过肝组织进行受体IL-28B rs12979860位点的基因多态性检测,观察病毒学应答及预后情况。结果 33例患者获得治疗结束时病毒学应答(end of treatment virologic response,ETVR)24例(72.7%),其中获得持续性病毒学应答(sustained virologic response,SVR)12例(36.4%)。受体的基因型分布:CC型25例(75.8%)、非CC型8例(24.2%)。CC型与非CC型患者中ETVR率分别为84.0%、37.5%,SVR率分别为44.0%、12.5%,二者比较,CC型获得ETVR率较高(P<0.05),SVR率差异无统计学意义(P>0.05);CC型及非CC型患者中抗病毒治疗后移植肝硬化率分别为8.0%、50.0%,二者比较,CC型患者移植肝硬化率较低(P<0.05)。结论受体IL-28B rs12979860位点CC基因型可能对移植术后丙型肝炎复发患者抗病毒治疗效果及预后存在有利影响。Objective To investigate the influence of recipient interleukin-28B（IL-28B） polymorphisms on the antiviral therapy and prognosis in patients with hepatitis C recurrence after liver transplantation. Methods Thirty-three patients with hepatitis C recurrence after liver transplantation were treated with interferon combined with Ribavirin. IL-28 B polymorphisms（rs12979860） was characterized using liver tissue from recipients. Virological response and prognosis were observed. Results Twenty-four（72. 7%） patients achieved ETVR,in who 12 cases（36. 4%） achieved SVR.The prevalence of CC genotype and non-CC genotype in recipient samples were 75. 8% and 24. 2%,respectively. The rate of ETVR（84. 0%） in patients with CC genotype was higher than the rate in patients with non-CC genotype（37. 5%）（P〈0. 05）. The difference of SVR rates between the CC genotype（44. 0%） and non-CC genotype（12. 5%） was not statistically significant（P〈0. 05）. The rate of transplanted liver cirrhosis after antiviral therapy in patients with genotype CC（8. 0%） was lower than the rate in patients with non-CC genotype（50. 0%）（P〈0. 05）. Conclusion The recipient CC genotype of IL-28B（rs12979860） may have beneficial influence on antiviral therapy and prognosis in patients with hepatitis C recurrence after liver transplantation.

关 键 词：IL-28B基因多态性 肝移植 丙型肝炎 抗病毒治疗 

分 类 号：R575.1[医药卫生—消化系统]