补益肝肾通络法联合左旋多巴片治疗帕金森病的研究  

Nourishing liver and kidney and dredging collaterals combined with Levodopa Tablets in treatment of Parkinson's disease

作　　者：李春丽[1] 郑卫莉[2] 

机构地区：[1]新疆维吾尔自治区人民医院北院,新疆乌鲁木齐830054 [2]新疆医科大学附属中医医院,新疆乌鲁木齐830011

出　　处：《现代中西医结合杂志》2017年第3期262-264,共3页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的观察补益肝肾通络法联合左旋多巴片治疗帕金森病对患者自主神经功能障碍的影响。方法将88例帕金森病患者随机分为对照组和观察组各44例,对照组给予左旋多巴片治疗,观察组在对照组治疗基础上加用自拟补益肝肾通络方治疗,2组疗程均为6个月。观察2组治疗前后自主神经症状量表(SCOPT-AUT)评分、中医症候(主症、次症)评分及统一帕金森病评分量表(UPDRS)评分变化情况。结果治疗6个月后,观察组SCOPTAUT评分和主症评分均明显降低(P均<0.05),对照组则均明显升高(P均<0.05),2组治疗后比较差异均有统计学意义(P均<0.05);2组UPDRS评分均明显降低(P均<0.05),且观察组UPDRS评分明显低于对照组(P<0.05)。对照组治疗3个月和6个月后次症评分均明显升高(P均<0.05);观察组治疗3个月后次症评分无明显变化(P>0.05),治疗6个月后明显降低(P<0.05);观察组治疗后各时间段次症评分均明显低于对照组(P均<0.05)。结论补益肝肾通络法联合左旋多巴片能在一定程度上延缓帕金森病患者自主神经功能障碍的发展。Objective It is to observe the influence of nourishing liver and kidney and dredging collaterals combined with Levodopa Tablets on autonomic nerve dysfunction in treatment of Parkinson＇s disease. Methods 88 patients with Parkinson＇s disease were randomly divided into control group and observation group,each with a total of 44 cases. The patients were treated with Levodopa Tablets in the control group,and with nourishing liver and kidney and dredging collaterals Decoction（NLKDCD） combined with Levodopa Tablets in the observation group. The course of treatment was 6 months in both groups. The autonomic nervous symptom scale（SCOPT-AUT） score,TCM syndrome（main symptom,secondary symptom） scores and the unified Parkinson Disease Rating Scale（UPDRS） scores were observed in two groups before and after treatment. Results After treatment for 6 months,the SCOPT-AUT scores and main symptom scores were significantly reduced in the observation group（all P〈0. 05）,but were significantly elevated in the control group（all P〈0. 05）,there was significant difference between the two groups（P〈0. 05）; the UPDRS scores of the two groups were significantly reduced（P〈0. 05）,and the UPDRS scores of the observation group were significantly lower than the control group（P〈0. 05）. After treatment for 3 months and 6months,the secondary symptom scores were significantly higher in the control group（all P〈0. 05）; there was no significant change of the second symptom score after treatment for 3 months（P〉0. 05）,and the score was significantly decreased after 6months in the observation group（P〈0. 05）; the second symptom score after treatment in the observation group were significantly lower than those of the control group（all P〈0. 05）. Conclusion The treatment of NLKDCD combined with Levodopa Tablets can delay the development of autonomic nerve dysfunction in patients with Parkinson＇s disease to a certain extent.

关 键 词：补益肝肾通络 帕金森病 自主神经功能障碍 

分 类 号：R742.5[医药卫生—神经病学与精神病学]