PSCA rs2294008基因变异对膀胱癌分级、分期的影响  

Genetic variant as a selection marker in PSCA and bladder cancer susceptibility

作　　者：杨峻峰[1] 余闫宏[1] 肖民辉[1] 章卓睿[1] 杨茂林[1] YANG Jun-feng YU Yan-hong XIAO Min-hui ZHANG Zhuo-rui YANG Mao-lin.(Department of Urology, First People＇s Hospital of Yunnan Province, Kunming 650032, Chin)

机构地区：[1]云南省第一人民医院泌尿外科,昆明650032

出　　处：《现代泌尿生殖肿瘤杂志》2016年第5期272-274,278,共4页Journal of Contemporary Urologic and Reproductive Oncology

基　　金：国家自然科学基金地区基金项目(81260375)

摘　　要：目的研究PScA rs2294008多态性是否与膀胱癌易感性相关。方法抽取235例膀胱癌患者和200例非膀胱癌患者的血样，进行基因型测定，确定患者血样中PSCArs2294008基因型，进行病例对照研究。结果rs2294008的基因型CC、CT和TT在膀胱癌患者中出现的概率分别为42．1％、47．7％、10．2％，在对照组中分别为52．0％、40．0％、8．0％；合并的CT／TT和CC基因型对比，合并基因型使膀胱癌风险显著增加（CT／TT：OR=1．37，95％CI1．08-1．74）。结论PSCA中rs2294008的基因多态性与膀胱癌的风险相关。Objective To investigate the association between the prostate stem cell antigen （PSCA） rs2294008 and bladder cancer. Methods We conducted a hospital-based case-control study of 235 cases and 200 controls. We genotyped the rs2294008 polymorpbism and assessed its associa- tion with risk of bladder cancer. Results The genotype of rs2294008 is CC, CT, and TT. In case group, the occurrence probability is 42.1%, 47.7%, 10.2%, and in control group, the occurrence probability is 52.0%, 40.0%, 8.0%. A significant increased risk of bladder cancer was found for rs2294008 CT/TT genotypes （adjusted odds ratio, 1.37; 95% confidence interval, 1.08-1.74） com- pared with the CC genotype. Conclusions These results indicated that the rs2294008 polymor- phism of PSCA gene may play a role in bladder cancer carcinogenesis and it could be served as a bio- marker for genetic susceptibility to bladder cancer.

关 键 词：膀胱肿瘤 多态性  单核苷酸 前列腺干细胞抗原 

分 类 号：R737.14[医药卫生—肿瘤]