基于修饰的β-环糊精的超分子体系研究及应用进展  

Progress in Study and Application of Supramolecular System Based on β-Cyclodextrin

作　　者：李琳琳[1] 段尊斌 朱丽君[1] 项玉芝[1] 夏道宏[1] 

机构地区：[1]中国石油大学(华东)重质油国家重点实验室,山东青岛266580

出　　处：《应用化学》2017年第2期123-138,共16页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金资助项目(21376265)~~

摘　　要：β-环糊精是一类环状的、由7个D-吡喃葡萄糖单元通过α-1,4-糖苷键连接而成的低聚糖,具有"内疏水、外亲水"的刚性锥形空腔结构。近年来,基于β-环糊精的超分子体系的制备及应用取得前所未有的显著进展。本文主要综述了β-环糊精衍生物、低聚物以及多聚物在合成方面的新进展,介绍了基于β-环糊精的分子组装,以及以β-环糊精及其修饰物为超分子主体的超分子体系在药物运输、基因传递、催化反应、污染治理等方面的最新应用。目前,对β-环糊精基本性质及应用的研究已日趋成熟,但仍存在许多实际性的问题需要解决。随着研究的进一步深入,有望实现β-环糊精在各领域的大规模、深层次应用。β-Cyclodextrin（β-CD） is a class of cyclic oligosaccharide which consists of seven D-galactose units linked by α-1,4-glycosidic bonds. β-CD has＇a rigid and cone-like molecular structure with hydrophilic outer surface and hydrophobic inner cavity. Recently, unprecedented progress about the preparation and application of supramolecular system based on β-CD has been made. In this paper, the synthesis of derivatives, oligomers and polymers ofβ-CD, molecular assemblies based on β-CD, and their latest application of supramolecular system that uses β-CD and its modifier as host in drug delivery, gene transfer, catalytic reaction, pollution control and so on, are reviewed. Until now, studies on basic properties of β-CD are becoming mature, but there are still some realistic problems remaining to be solved. With further studies, wider and deeper applications of β-CD may be finally achieved in various fields.

关 键 词：Β-环糊精 修饰物 超分子 组装 应用 

分 类 号：O641.3[理学—物理化学]