三(邻甲基苄基)锡和二(间氟苄基)锡硫代水杨酸酯配合物的合成、结构及性质  

Synthesis,Structures and Properties of Tris( o-methylbenzyl) tin Thiosalicylate and Di( m-fluorobenzyl) tin Thiosalicylate

作　　者：张复兴[1] 邝代治[1] 李璇捷 冯泳兰[1] 王剑秋[1] 庾江喜[1] 蒋伍玖[1] 朱小明[1] 

机构地区：[1]衡阳师范学院化学与材料科学学院,功能金属有机材料湖南省普通高等学校重点实验室,湖南衡阳421008

出　　处：《应用化学》2017年第2期163-171,共9页Chinese Journal of Applied Chemistry

基　　金：湖南省高校创新平台开放基金项目(15K017,14K014,13K105);湖南省自然科学基金(13JJ3112);湖南省科技计划(2014NK3086);湖南省重点学科基金;湖南省高校科技创新团队支持计划;湖南省大学生研究性学习和创新性实验项目;湖南省教育厅基金(15C0199,15CO200)资助~~

摘　　要：合成了三(邻甲基苄基)锡硫代水杨酸酯配合物(1)和一维链状二(间氟苄基)锡硫代水杨酸酯配合物(2),经元素分析、IR、NMR、X射线衍射等技术手段表征了其结构。配合物1属三斜晶系,空间群Pī,晶体学参数a=1.00221(5)nm,b=1.48934(8)nm,c=1.71789(9)nm,α=78.3120(10)°,β=85.6560(10)°,γ=80.2580(10)°,V=2.4725(2)nm^3,Z=2,Dc=1.371 g/cm^3,μ(Mo Kα)=10.91 cm^(-1),F(000)=1040,R_1=0.0439,wR_2=0.1119。配合物2属单斜晶系,空间群为P21/n,晶体学参数:a=1.17827(5)nm,b=2.11945(9)nm,c=1.55970(7)nm,β=93.4510(10)°,V=3.8880(3)nm^3,Z=4,Dc=1.671 g/cm^3,μ(Mo Kα)=14.53 cm^(-1),F(000)=1936,R1=0.0323,wR2=0.0927。配合物1中锡原子呈四配位畸变四面体构型,配合物2中锡原子呈五配位畸变三角双锥构型。配合物1和2分别在152和195℃下稳定,电化学性质不可逆,对人体癌细胞Colo205、Hep G2、MCF-7、Hela和NCI-H460具有体外抗癌活性,配合物2的抗癌活性远大于配合物1。Tris （o-methylbenzyl） tin thiosalicylate （ 1 ） and di （m-fluorobenzyl） tin thiosalicylate （2） have been synthesized. Crystal structures of the complexes were determined by X-ray diffraction. Crystal I belongs to the triclinic space group Pi with a=1.00221（5）nm,b=1.48934（8）nm,c=1.71789（9）nm,α=78.3120（10）°,β=85.6560（10）°,γ=80.2580（10）°,V=2.4725（2）nm3,Z=2,Dc=1.371 g/cm3,μ（Mo Kα）=10.91 cm-1,F（000）=1040,R1=0.0439,wR2=0.1119. Crystal 2 belongs to the monoclinic space group P2/n with a=1.17827（5）nm,b=2.11945（9）nm,c=1.55970（7）nm,β=93.4510（10）°,V=3.8880（3）nm3,Z=4,Dc=1.671 g/cm3,μ（Mo Kα）=14.53 cm-1,F（000）=1936,R1=0.0323,wR2=0.0927. The tin atoms in complexes 1 and 2 have four coordinates in a distorted tetrabedral configuration and five coordinates in a distorted trigonal bipyramidal configuration, respectively. Further more, the thermal stability and electrochemical and anticaneer activity of the complexes were tested. The results show that complexes 1 and 2 are stable below 152℃ and below 195℃, respectively, and show irreversible redox process. Complexes 1 and 2 display in vitro anti-tumor activity against five human tumor cell lines Colo205, Hep G2, MCF-7, Hela and NCI-H460, and the anti-tumor activity of complex 2 is higher than that of complex 1.

关 键 词：三(邻甲基苄基)锡硫代水杨酸酯 二(间氟苄基)锡硫代水杨酸酯 合成 结构 抗癌活性 

分 类 号：O614.4[理学—无机化学]