JAB1在胆囊癌中的表达及临床病理意义  

The expression of JAB1 in gallbladder carcinoma and its clinical significance

作　　者：顾国建[1] 顾凤华[1] 练玲芝[1] 

机构地区：[1]苏州大学附属太仓市第一人民医院病理科,江苏215400

出　　处：《中国临床新医学》2017年第1期9-11,共3页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：太仓市重点研发计划(社会发展)课题(编号:TC2015SFYL10)

摘　　要：目的研究C-Jun激活域结合蛋白1(C-Jun activation domain binding protein 1,JAB1)在胆囊癌组织中的表达,探讨其临床病理意义。方法采用免疫组化方法检测JAB1在65例胆囊癌组织和15例慢性胆囊炎组织中的表达情况。结果胆囊癌组织中JAB1蛋白阳性率为60.0%,显著高于慢性胆囊炎组织(13.3%)(P<0.05)。结论 JAB1蛋白表达增高与胆囊癌发生、发展密切相关,检测JAB1蛋白有助于胆囊癌的早期诊断及判断患者预后。Objective To investigate the expression of C-Jun activation domain binding protein 1 （ JAB1 ） in human gallbladder carcinoma（GA）. Methods The expressions of JAB1 protein were detected in 65 cases with GA and in 15 cases with chronic choleeystitis by immunohistochemical method. Results The positive expression level of JAB1 in the pateints with GA（ 60. 0% ） was significantly higher than that in the pateints with chronic cholecystitis （ 13.3 % ） （P 〈 0. 05）. Conclusion Elevated expression of JAB1 is closely correlated with GA, and the detection of JAB1 may be helpful to evaluate the early diagnosis and prognosis of GA.

关 键 词：胆囊癌 C-Jun激活域结合蛋白1 免疫组织化学 

分 类 号：R735.8[医药卫生—肿瘤]