儿童急性淋巴细胞性白血病化疗前后红细胞体积分布宽度的变化及临床意义  

Clinical significance of red cell distribution width in children acute lymphoblastic leukemia before and after chemotherapy

作　　者：王鸿武[1] 林丽敏[1] 

机构地区：[1]汕头大学医学院第二附属医院儿内科,广东汕头515041

出　　处：《吉林医学》2016年第12期2887-2888,共2页Jilin Medical Journal

摘　　要：目的:探讨急性淋巴细胞性白血病患儿红细胞体积分布宽度(RDW)变化的临床意义。方法:正常对照组70例;急性淋巴细胞性白血病组68例。采用血细胞自动分析仪检测研究对象外周血红细胞体积分布宽度和其他各种红细胞参数。结果:红细胞体积分布宽度(RDW)正常对照组为12.86±0.77,急性淋巴细胞性白血病化疗前组为17.32±2.08,与正常对照组相比RDW值明显升高,差异有统计学意义(P<0.05);急性淋巴细胞性白血病经规则化疗达到完全缓解后红细胞体积分布宽度(RDW)为14.38±1.92,与化疗前组相比RDW值差异有统计学意义(P<0.05)。结论:急性淋巴细胞性白血病患儿红细胞有质和量的异常变化,化疗缓解后RDW值明显改善,对判断急性淋巴细胞性白血病化疗后是否缓解有一定的参考价值。Objective To investigate the clinical significance of the change of red cell distribution width （RDW） in children acute lymphoblastic leukemia. Method 70 cases of normal control group and 68 cases of acute lymphoblastic leukemia group. This research used automatic blood cell analyzer to detect the peripheral red cell distribution width and other parameters of red blood cell. Results Red cell distribution width （RDW） of normal control group was 12. 86 ± 0. 77, and acute lymphoblastic leukemia before chemotherapy group was 17. 32 ± 2. 08, compared with the normal control group values were significant difference （P 〈 0. 05 ） ; RDW of acute lymphoblastic leukemia by the planning chemotherapy achieves complete remission was 14. 38 ± 1.92, compared with acute lymphoblastie leukemia before chemotherapy group values were significant difference （ P 〈 0. 05）. Conclusion Abnormal changes of quality and quantity of red cells in children acute lymphocytic leukemia. And RDW value significantly improved in children acute lymphocytic leukemia achieves complete remission after chemotherapy. RDW value use to determine whether the remission of acute lymphoblastic leukemia after chemotherapy has a certain reference value.

关 键 词：急性淋巴细胞性白血病 儿童 红细胞体积分布宽度 

分 类 号：R733.71[医药卫生—肿瘤]