116例稽留流产患者绒毛细胞培养及其染色体核型分析  

Culture and karyotype analysis of chorionic villus cells in 116 cases of missed abortion

作　　者：胡道琴[1] 孙淑湘[2] 赵少翠 HU Dao-qin SUN Shu- xiang ZHAO Shao-cui(Department of Gynecology Department of Genetic Medicine, the Maternal and Child Health Care Hospital of Jiangmen, Jiangmen, GuangDong529000, China)

机构地区：[1]江门市妇幼保健院妇科,广东江门529000 [2]江门市妇幼保健院医学遗传中心,广东江门529000

出　　处：《中国优生与遗传杂志》2017年第1期44-45,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨绒毛染色体异常与稽留流产的关系。方法取116例稽留流产患者绒毛进行细胞培养和染色体核型分析。结果 111例患者绒毛染色体培养成功,绒毛细胞培养成功率95.7%。其中绒毛染色体核型异常43例,核型异常发生率为38.7%。染色体数目异常39例,占异常核型的90.7%,其中常染色体三体21例,占异常核型的48.8%;其次为多倍异常,共16例,占异常核型的37.2%。结论染色体数目异常是稽留流产的重要原因,绒毛染色体核型分析是稽留流产病因诊断的重要手段,可为再次生育提供优生指导依据。Objective： To explore the relationship between chromosome abnormity of chorionic villus and missed abortion. Methods： Chorionic villus were obtained from 116 cases of missed abortion, and cultured for karyotype analysis. Results： Chorionic villus cells were successfully cultured in 111cases of the 116 cases （95.7%） , and abnormal embryo karyotype were involved in 43 cases （38.7%） .39 cases （90.7%） were detected to be abnormal chromosome number, including 21 cases （48.8%） trisomy and 16 cases （37.2%） polyploidy. Conclusions： Abnormal chromosome number is one of the main cause of missed abortion. Villus chromosome karyotype analysis is a very important means of discussing the pathogeny of missed abortion. which can provide reasonable guidance on the next pregnancy patients.

关 键 词：稽留流产 绒毛 染色体异常 核型分析 

分 类 号：R714.21[医药卫生—妇产科学]