超声NT测量与血清β-HCG及PAPP-A检测在孕1113^+6W唐氏征筛查中的临床应用分析  

Clinical application analysis of tang sieve for ultrasonic NT measurement and serum β-HCG and PAPP-A detection in the 11~13^(+6) weeks of pregnant women

作　　者：陈寸 何娟[1] 吉文倩 CHEN Cun HE Juan JI Wen-qian.(Department of B Ultrasonic, Maternity and Child Health Care Hospital of Sanya, 572000, Hainan, Chin)

机构地区：[1]三亚市妇幼保健院B超科,海南三亚572000

出　　处：《中国优生与遗传杂志》2017年第1期78-80,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨超声NT测量与血清β-HCG及PAPP-A检测在孕11~13^(+6)w唐筛中的作用和意义,以期对现有研究数据进行补充,从而为临床诊疗提供指导。方法回顾性三亚市妇幼保健院2014年08月至2016年08月期间经临床确诊为唐氏综合征的孕11~13^(+6)w单活胎妊娠孕妇38例,且均予实施超声NT测量与血清β-HCG及PAPP-A检测。最终根据资料分析单一筛查与联合筛查的结果。结果经超声NT测量的阳性率为84.21%(32/38),经血清β-HCG及PAPP-A检测的阳性率为76.32%(29/38),经超声NT测量联合血清β-HCG及PAPP-A检测的阳性率为97.37%(37/38)。其中,联合筛查较单一筛查,差异均有统计学或显著性统计学意义(P<0.05或0.01)。但是,单一筛查之间比较,差异无统计学意义(P>0.05)。结论超声NT测量与血清β-HCG及PAPP-A检测在孕11~13^(+6)w唐筛中不能互相取代,两者联合筛查可提高筛查的精准性,对诊断胎儿唐氏综合征有着积极的作用和意义。Objective： To explore the functions and importance of tang sieve for ultrasonic NT measurement and serum β-HCG and PAPP-A detection in the 11 - 13 ＋6 weeks of pregnant women in order to supplement existing research data so that to provide guidance for clinical diagnosis and treatment. Methods： Retrospectively during August 2014 to August 2016 by the clinical diagnosis of down syndrome 11 - 13＋6 weeks of single live pregnancy pregnant women 38 cases, who were come from Maternity and Child Health Hospital of Sanya. And to implement the ultrasonic NT measurement and serum β-HCG and PAPP-A detection. According to data analysis the results of a single screening and combined screening. Results： The positive rate was 84.21% （32/38） of ultrasonic NT measurement, the β-HCG and PAPP-A detection of serum positive rate was 76.32% （29/38） and by ultrasound NT measuring combined ^-HCG and PAPP-A detection of serum positive rate was 97.37% （37/38） . Among them, the comparation of a single screening, differences have statistical or significant statistical significance （P〈0.05 or 0.05） . However, comparison between a single screening, there was no statistically significant difference （P〉0.05） . Conclusion： The tang sieve for ultrasonic NT measurement and serum β-HCG and PAPP-A detection in the 11- 13 ＋6 weeks of pregnant women can not replace each other. The combination of both can improve the precision. For diagnosing fetal down syndrome have positive function and meaning.

关 键 词：唐氏综合征 颈项透明层厚度 游离人绒毛膜促性腺激素β亚基 妊娠相关蛋白A 孕1113+6W 

分 类 号：R714.55[医药卫生—妇产科学]