巨噬细胞抑制因子-1及胃泌素释放肽前体水平对肺癌患者的诊断和预后评估价值  

Diagnostic and Prognosctic Prediction Value of Macrophage Inhibitory Factor-1 and Pro-gastrin Releasing Peptide Level in Patients with Lung Cancer

作　　者：孙莹 张影[2] 宋昕 祁志荣 赖杰 王丽[3] SUN Ying ZHANG Ying SONG Xin QI Zhi-rong LAI Jie WANG Lr(I The medical department of cadres, China Meitan General Hospital, Beijing, 100028, China Department of internal medicine, the Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing, 100012, China Department of internal medicine, integrated traditional Chinese and Western medicine hospital ofJilin, Changchun, Jilin, 132400, China)

机构地区：[1]煤炭总医院干部医疗科,北京100028 [2]吉林中西医结合医院内科,吉林长春132400 [3]北京中医药大学第三附属医院内科,北京100012

出　　处：《现代生物医学进展》2016年第35期6869-6871,6816,共4页Progress in Modern Biomedicine

基　　金：吉林省科技发展计划基金项目(990575-5)

摘　　要：目的:研究巨噬细胞抑制因子-1(MIC-1)及胃泌素释放肽前体(pro-GRP)水平对肺癌患者的诊断和预后评估价值。方法:选择2012年5月-2015年6月在我院确诊的50例肺癌患者和35例肺良性占位性病变患者分别作为肺癌组和良性对照组,同一时间段内在我院体检的50例健康者作为健康对照组,采集血清并测定MIC-1、pro-GRP、CEA、CA125、CYFRA21-1、SCC-Ag的含量。结果:肺癌组患者血清中MIC-1、pro-GRP的含量(1.19±0.18 vs 0.42±0.07,0.37±0.05 ng/m L)、(363.62±65.61 vs 62.42±9.61,57.24±8.94 pg/m L)显著高于良性对照组和健康对照组;肺癌患者的TNM分期越高、分化程度越低,血清中MIC-1、pro-GRP的含量越高且远处转移患者的血清MIC-1、pro-GRP含量显著高于未发生远处转移的患者;肺癌组患者血清中CEA、CA125、CYFRA21-1、SCC-Ag的含量显著高于良性对照组和健康对照组并且与血清MIC-1、pro-GRP含量呈正相关。结论:肺癌患者的血清MIC-1和pro-GRP含量显著升高,与肺癌的临床病理特征以及恶性程度均具有相关性。Objective： To study the predictive value of macrophage inhibitory factor -1 and pro-gastrin releasing peptide level in patients with lung cancer. Methods： 50 cases of patients with lung cancer and 35 cases patients with lung benign lesions diagnosed in our hospital from May 2012 to 2015 June were respectively enrolled in lung cancer group and benign control group, 50 cases of healthy people received physical examination during the same time section in our hospital were enrolled as healthy control group. Serum was collected and MIC-1, pro GRP, CEA, CA125, CYFRA21-1, SCC Ag contents weredetermined. Results： Serum MIC-1 （1.19±0.18 vs 0.42± 0.07, 0.37±0.05 ng/mL）, pro-GRP（363.62± being 65.61 vs 62.42±9.61, 57.24± 8.94 pg/mL） content of lung cancer group were significantly higher than those in benign control group and healthy control group; in patients with lung cancer, the higher the TNM stage and the lower the differentiation degree, the higher the serum MIC-1, pro GRP contents and serum MIC-1, pro-GRP contents of patients with distant metastasis were significantly higher than those without distant metastases; serum CEA, CA125, CYFRA21-1, SCC Ag contents of lung cancer group were significantly higher than those of benign control group and healthy control group and positively correlated with serum MIC-1, pro-GRP contents. Conclusion： The serum MIC-1 and pro-GRP levels of lung cancer patients significantly increase, serum MIC-1 and pro-GRP levels correlate with the clinicopathological characteristics and the degree of malignancy.

关 键 词：肺癌 巨噬细胞抑制因子-1 胃泌素释放肽前体 肿瘤标志物 

分 类 号：R734.2[医药卫生—肿瘤]