吲哚菁绿和亚甲蓝在乳腺癌前哨淋巴结活检中的应用对比研究  

Comparative Study of Indocyanine Green and Methylene Blue in Sentinel Lymph Node Biopsy

作　　者：汪瑞[1,2] 周军[1] 毕铁强[1] 董天赋[1] 沈俊[1] 王培顺[1] 李淑琴[1] 高希涛[1] 王岩[1] 王昭昕[1] WANG Rui ZHOU Jun BI Tie-qiang DONG Tian-fu SHEN Jun WANG Pei-shun LI Shu-qin GA O Xi-tao WANG Yan WANG Zhao-xin(Department of Mammary Surgery, the First People＇s Hospital of Lianyungang City, Lianyungang, Jiangsu, 222002, China Xuzhou Medical College, Xuzhou, Jiangsu, 221004, China)

机构地区：[1]江苏省连云港市第一人民医院甲乳外科,江苏连云港222002 [2]徐州医学院研究生学院,江苏徐州221004

出　　处：《现代生物医学进展》2016年第35期6926-6928,6865,共4页Progress in Modern Biomedicine

基　　金：江苏省高校自然科学研究重大项目(13KJA360158)

摘　　要：目的:比较吲哚菁绿和亚甲蓝在乳腺癌前哨淋巴结活检中的临床疗效。方法:选取我院2014年3月至2016年3月期间收治的240例乳腺癌患者,随机分为荧光组(n=120)及染色组(n=120),其中以吲哚菁绿作为示踪剂为荧光组,以亚甲蓝作为示踪剂为染色组,两组患者行前哨淋巴结活检结术后,行I、II水平腋窝淋巴清扫,比较术后两种示踪剂检出率、假阴性率及前哨淋巴结(SLN)检出个数,比较S型与M型淋巴引流的患者比例差异。结果:荧光组前哨淋巴结检出率为99.7%(116/120),染色组为93.3%(112/120),与染色组相比,荧光组检出率提高,组间比较数据具有统计学意义(P<0.05),荧光组假阴性率为5.2%,染色组假阴性率为8.4%,两组平均检出前哨淋巴结数量分别为荧光组(4.4±1.5)枚,染色组(4.2±1.6)枚,组间数据无统计学意义(P>0.05)。结论:吲哚菁绿检出率高于染料法,更适合作为前哨淋巴结活检术示踪剂。Objective： To compare clinical effects ofindocyanine green （ICG） and methylene blue in sentinel lymph node （SLN） biopsy. Methods： Select 240 cases of breast cancer patients in our hospital in this study. They were randomly divided into ICG group （n=120） and staining group （n=120）. Indocyanine green was taken as a tracer for the ICG group, while methylene blue as a tracer for the staining group. After sentinel lymph node biopsy, patients got level I, II axillary lymph node dissection. After operation, we compared the detection rate, false negative rate and SLN detection number between two kinds of tracers. The number of SLN is represented by （x＋ s）. Compare the ratios of patients with lymphatic drainage type S or M. Results： The sentinel lymph node detection rate was 99.7% （116/120） in ICG group, and 93.3% （112/120） in staining group. The ICG group had higher detection rate than staining group, and the difference had statistical significance （P〈0.05）. The false negative rate was 5.2% in ICG group, and was 8.4% in staining group. The mean number of sentinel lymph node detected out was （4.4± 1.5） pieces in ICG group, and （4.2±1.6） pieces in staining group, and the data between the two groups had no statistical differences （P〉0.05）. Conclusion： Indocyanine green made higher detection rate than the dye method, so it was more suitable as sentinel lymph node biopsy tracer.

关 键 词：乳腺癌 前哨淋巴结 活组织检查 示踪剂 

分 类 号：R737.9[医药卫生—肿瘤]