原发性开角型青光眼患者血流变学与血流动力学的相关性  

Correlation between Blood Rheology and Hemodynamics in Patients with Primary Open Angle Glaucoma

作　　者：都艳红 丁洁[1] 张士宏[1] 王艳新[1] 高艳茹[1] 刘晔青[1] 蔡金玲[1] 张丹[1] 夏春晓[1] DU Yan-hong DING Jie ZHANG Shi-hong WANG Yan-xin GA O Yan-ru LIU Ye-qing CAI Jin-ling ZHANG Dan XIA Chun-xiao(Department of Ophthalmology, Baoding Second Central Hospital of Hebei Province, Banding, Hebei, 072750, Chin)

机构地区：[1]河北省保定市第二中心医院眼科,河北保定072750

出　　处：《现代生物医学进展》2016年第35期6952-6954,6935,共4页Progress in Modern Biomedicine

摘　　要：目的:分析原发性开角型青光眼(POAG)患者的血流变学与血流动力学,并探讨两者之间的相关性。方法:收集2015年1月至2016年6月我院收治的43例(51只眼睛)POAG患者为病例组,并于同期随机抽取25例(50只眼睛)健康体检自愿者为对照组,测定两组的血流变学指标如纤维蛋白原、全血比粘度、血浆比粘度水平,采用彩色多普勒超声诊断仪检测两组视网膜中央动脉(CRA)、眼动脉(OA)的频谱,并对比两组血流动力学指标如阻力指数值(RI)、收缩期峰值血流速度(PSV)、舒张末期血流速度(EDV)。结果:病例组的纤维蛋白原、低切、高切的全血比粘度及血浆粘度均高于对照组,差异有统计学意义(P<0.05)。病例组CRA、OA的RI水平高于对照组,PSV、EDV水平低于对照组,差异有统计学意义(P<0.05)。病例组患者血流变学参数纤维蛋白原、低切、高切的全血比粘度及血浆粘度与血流动力学参数RI呈正相关关系,与PSV、EDV呈负相关关系,差异有统计学意义(P<0.05)。结论:POAG患者存在不同程度的血液循环障碍,联合检测血流变学和血流动力学可作为诊断和评估原发性开角型青光眼预后的重要指标。Objective： To analyze the blood rheology and hemodynamics in patients with primary open angle glaucoma and explore its relationship. Methods： 43 patients （n=51 eyes）with primary open angle glaucoma treated in our hospital from January 2015 to June 2016 were collected as case group, at the same time, 25 healthy volunteers （n=50 eyes）were selected as control group. The blood rheology parameters such as fibrinogen, whole blood specific viscosity, plasma ratio viscosity of the two groups were detected, the spectrum of central retinal artery （CRA） and ophthalmic artery （OA） in two groups were detected by color Doppler ultrasound, and hemodynamic parameters such as resistance index （RI）, peak systolic velocity （PSV）, end diastolic velocity （EDV） were compared between the two groups. Results： The fibrinogen, low shear and high shear whole blood viscosity, plasma ratio viscosity of case group were higher than those of control group, the differences were statistically significant （P〈0.05）. The RI in CRA, OA of case group was higher than that of control group respectively, and the PSV, EDV in CRA, OA of case group were lower than those of control group respectively, the dif- ferences were statistically significant （P〈0.05）. The fibrinogen, low shear and high shear whole blood viscosity, plasma ratio viscosity of blood rheology in patients with primary open angle glaucoma were positive association with RI of hemodynamics, which were negative association with PSV, EDV of hemodynamics, the differences were statistically significant（P〈0.05）. Conclusion： There are blood circulation disorder with different degrees in patients with primary open angle glaucoma, joint detection of blood rheology and hemodynamics can be used to be an important indicator for the diagnosing and evaluating prognosis of primary open angle glaucoma.

关 键 词：原发性开角型青光眼 血流变学 血流动力学 相关性 

分 类 号：R775[医药卫生—眼科]