老年脑出血患者血清cFN水平变化及其临床意义  被引量:7

Changes of serum cFN level in elderly patients with intracerebral hemorrhage and its clinical significance

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作  者:何金邦 赵晓萍 赵秀欣[3] 孙雅洁 

机构地区:[1]河北南堡盐场有限公司医院,河北063305 [2]解放军陆军总医院 [3]北京回龙观医院

出  处:《脑与神经疾病杂志》2017年第2期67-70,共4页Journal of Brain and Nervous Diseases

摘  要:目的探讨脑出血(ICH)老年患者血清人细胞纤维连接蛋白(cFN)的表达水平及其临床意义。方法以2014年3月-2015年12月在本院接受治疗的50例ICH老年患者为观察对象,同时选取50例健康老年人作为对照组。观察两组患者血清cFN、炎症细胞因子水平,比较死亡和未死亡ICH患者血清cFN、炎症细胞因子水平的差异。分析cFN与炎症细胞因子水平的相关性。结果 ICH组患者血清cFN、白介素-6(IL-6)、超敏反应C蛋白(hs-CRP)和肿瘤坏死因子-α(TNF-α)水平明显高于对照组(P<0.05);死亡的ICH患者其血清cFN、IL-6、hs-CRP和TNF-α水平明显高于未死亡者(均P<0.05);不同NIHSS评分患者的cFN、炎症细胞因子水平由高到低分别为≥15分者、8~14分者和≤7分者(均P<0.05);cFN水平与NIHSS评分、IL-6、hs-CRP和TNF-α水平显著正相关(r=0.420、0.356、0.412、0.398,均P<0.05)。结论 ICH老年患者血清cFN水平较高,且其水平与患者的神经功能缺损程度和细胞因子水平密切相关。Objective To explore the expression and clinical significance of patients with serum human cell fibronectin ( cFN ) in elderly patients with intracerebral hemorrhage ( ICH ) . Method 50 cases of elderly patients with ICH treated in our hospital from March 2014 to December 2015 were selected as the observation objects, and 50 healthy elderly were selected as the control group. The serum level of cFN and inflammatory cytokines in two groups were observed, and the levels of serum cFN and inflammatory cytokines in patients with death and non death ICH were compared. Analysis of the correlation between cFN and inflammatory cytokines levels. Results The level of serum cFN, IL-6, hs-CRP and TNF- ot in the ICH group were significantly higher than those in the control group, the difference was statistically significant; The serum level of cFN, IL-6, hs-CRP and TNF-were significantly higher than those of the patients who died of ICH, and the difference was statistically significant ( P〈0.05 ) ; Patients with different NIHSS score of the eFN, levels of inflammatory cytokines from high to low, respectively was more than or equal to 15 points, 8-14 points and less than or equal to 7 persons ( P〈0,05 ) ; cFN levels were significantly positively correlated with NIHSS score, IL-6, hs-CRP and TNF-levels ( r=0.420, 0.356, 0.412, 0.398, P〈0.05 ) . Conclusion Elderly patients with ICH in serum of patients with human plasma fibronectin level is better, and its level in patients with nerve function defect degree and cytokine levels closely related.

关 键 词:脑出血 人细胞纤维连接蛋白 细胞因子 相关性 

分 类 号:R743.34[医药卫生—神经病学与精神病学]

 

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