吉西他滨联合长春瑞滨治疗紫杉醇耐药的晚期老年非小细胞肺癌疗效观察  

Effect of Gemcitabine Combined with Vinorelbine on Paclitaxel Resistant Advanced Non-small Cell Lung Cancer in Elderly

作　　者：罗建华[1] 李俏俏[1] 潘君素 

机构地区：[1]台州市立医院呼吸内科,浙江台州318000

出　　处：《药物流行病学杂志》2017年第1期10-12,26,共4页Chinese Journal of Pharmacoepidemiology

摘　　要：目的:观察吉西他滨联合长春瑞滨(GN方案)治疗紫杉醇耐药的晚期老年非小细胞肺癌(NSCLC)的临床效果。方法:70例Ⅲ期与Ⅳ期的NSCLC老年患者随机分为观察组和对照组,每组35例,入组前所有患者均经过紫杉醇+顺铂连续治疗3个周期但效果不佳。观察组给予吉西他滨+长春瑞滨方案化疗,对照组只采用吉西他滨化疗,所有患者均连续治疗3个以上周期。比较两组近期疗效、药品不良反应,以及平均生存期、1年生存率等指标。结果:两组患者均进行3个周期以上的化疗。两组完成化疗周期比较,差异无统计学意义(P>0.05)。两组化疗后RR比较,差异也无统计学意义(P>0.05)。观察组的平均生存期和1年生存率均优于对照组(P<0.05)。两组患者药物不良反应主要为骨髓抑制、消化道反应、外周静脉炎等,差异无统计学意义(P>0.05)。结论:吉西他滨联合长春瑞滨化疗对NSCLC晚期老年患者有一定临床疗效,可延长患者生存期,患者耐受性较佳,值得实践推广。Objective： To observe the clinical effect of gemcitabine combined vinorelbine（ GN） on the treatment of paclitaxel resistant advanced non-small cell lung cancer（ NSCLC） in elderly. Methods： 70 cases with stage Ⅲ and ⅣNSCLC elderly patients were divided into the observation group and the control group,each group of 35 cases. Before that,all patients were given paclitaxel ＋ cisplatin treatment of three chemotherapeutic cycles with poor effects. The observation group was given gemcitabine ＋ vinorelbine chemotherapy. While patients in control group were treated with gemcitabine only. All patients were treated with three or more chemotherapeutic cycles. The effect of chemotherapy,adverse drug reactions,average survival period and one-year survival rate of two groups were compared. Results： Two groups of patients were treated more than three chemotherapy cycles. There had no statistical significance compared with the two groups＇ cycles（ P〈0. 05）. While compared with the two groups＇ RR after chemotherapy,there had no statistical significance either（ P〈0.05）. The average survival period and one-year survival rate of observation group was superior to the control group（ P〈0.05）. The Adverse drug reactions of two groups were mainly in bone marrow suppression,gastrointestinal reaction and peripheral phlebitis,and the differences were not statistically significant（ P〈0. 05）. Conclusion： For patients with advanced NSCLC in elderly,gemcitabine combined vinorelbine were effective in clinical chemotherapy. It could prolong survival in patients with stage,patients tolerated is better,and worth popularizing practice.

关 键 词：晚期非小细胞肺癌 老年 长春瑞滨 吉西他滨 化疗 

分 类 号：P079.1[天文地球]