宫颈鳞癌治疗后HR-HPV转阴规律及其相关因素分析  

Analysis of the regression rules of HR-HPV and its related factors in patients with cervical squamous cancer after treatment

作　　者：宋丹[1] 孔为民[1] 韩超[1] 刘婷婷[1] 张同庆[1] 焦思萌[1] 陈娇[1] 

机构地区：[1]首都医科大学附属北京妇产医院妇瘤科,100006

出　　处：《中国妇产科临床杂志》2017年第1期7-9,共3页Chinese Journal of Clinical Obstetrics and Gynecology

基　　金：北京市科委重点项目(D131100005313009)

摘　　要：目的探讨宫颈鳞癌患者治疗后高危型人乳头瘤病毒(HR-HPV)感染的转阴规律,并分析影响其转阴的相关因素。方法收集2011年1月至2012年12月在首都医科大学附属北京妇产医院接受治疗的宫颈鳞癌患者148例,其治疗前HR-HPV检测均阳性,观察宫颈鳞癌治疗后HR-HPV感染的转阴情况。结果 (1)148例宫颈鳞癌患者接受治疗后,至随访期结束HR-HPV转阴的患者共134例(90.5%);(2)其中随访0.5、1、1.5、2、2.5及3年后HR-HPV转阴率分别为68.9%、73.0%、77.7%、83.1%、86.5%及87.8%;(3)不同时间HR-HPV转阴的速率不同,以2年内转阴的速率最快,之后减慢;(4)单因素及多因素分析均显示临床分期、治疗方案及HPV分型是影响HR-HPV转阴的因素(P<0.05),而年龄、组织学分级、吸烟及是否使用安全套不是影响HR-HPV转阴的因素(P>0.05)。结论 (1)宫颈鳞癌治疗后HR-HPV转阴率逐年升高,半年内转阴率达68.9%,以2年内转阴速率最快;(2)临床分期、治疗方案及HPV分型是影响HR-HPV转阴的主要因素。Objective To investigate the regression regularity of HR-HPV in patients with cervical squamous cancer after treatment and to determine its correlative factors. Methods The clinical data in patients with cervical squamous cancer who were treated in Beijing Obstetrics and Gynecology Hospital from January 2011 to December 2012 were collected and sorted. All patients had positive HR-HPV before treatment. Results ① Among the 148 cases with cervical squamous cancer after treatment, a total of 134 patients had negative HR-HPV to the end of the follow-up period, the others had persisting positive HR-HPV. ② The clearance rate of half a year, one year, one year and a half, two years, two years and a half and three years was 68.9%, 73.0%, 77.7%, 83.1%, 86.5% and 87.8% respectively. ③ The line chart showed that the clearance rate increased the fastest in the first two years, then slowed down. ④ The univariate analysis and the multivariate analysis showed that the effects were significantly different with clinical stage, treatment regimens and different types of HR-HPV （P〈0.05）. The age, histological grade, smoking and the use of condom were not the related factors （P〉0.05）. Conclusions ① The clearance rate of HR-HPV increased year by year and increased the fastest in the first two years after cervical squamous cancer treatment. The clearance rate reached 68.9% within half a year. ② The clinical stage, treatment regimens and different types of HPV were correlative factors of the regression of HR-HPV.

关 键 词：宫颈鳞癌 高危型人乳头瘤病毒 转阴 

分 类 号：R737.33[医药卫生—肿瘤]