Hpa的表达与子宫内膜癌侵袭性关系  

Expression of heparanase and the invasive ability of endometrial carcinoma

作　　者：王孝忠[1] 刘丹[1] 胡喜珍[1] 王玉凤[1] 陈小琴[1] 兰玉[1] 

机构地区：[1]广州市红十字会医院、暨南大学医学院附属广州红十字会医院妇产科,510220

出　　处：《中国妇产科临床杂志》2017年第1期29-32,共4页Chinese Journal of Clinical Obstetrics and Gynecology

基　　金：广州市海珠区科技计划项目(2009-Y-019)

摘　　要：目的研究Hpa在子宫内膜组织中的表达情况及其与子宫内膜癌侵袭性的关系。方法采用免疫组化SABC法检测105例子宫内膜癌组织,正常子宫内膜、单纯性增生、复杂性增生及不典型增生子宫内膜组织各30例中Hpa的表达。结果 Hpa在正常子宫内膜、子宫内膜增殖症及子宫内膜癌中的表达呈递增趋势(P<0.05),Hpa在子宫内膜癌中的表达与其病理类型、临床分期、组织分化程度以及有无淋巴结转移密切相关。结论 Hpa与子宫内膜癌的侵袭性相关,对Hpa的抑制有望作为子宫内膜癌的一个治疗靶点。Objective To investigate the expression of Hpa in endometrial tissue and its relationship with the invasive ability of endometrial carcinoma. Methods The expression of Hpa was determined by SABC method in 105 endometrial cancerous tissue, 30 normal hyperplasia of endometrium, 30 simple hyperplasia, 30 complexity and 30 atypical hyperplasia. Results Hpa expression in normal endometrium, endometrial hyperplasia and endometrial carcinoma tissue expressed the gradient increasing trend （p〈 0.05）, Hpa is closely related to pathological type, clinical stage, tissue differentiation degree and the presence of lymph node metastasis of endometrial carcinoma. Conclusion Hpa is associated with the invasive ability of carcinoma endometrium, and maybe act as a therapeutic targets of endometrial carcinoma.

关 键 词：子宫内膜癌 乙酰肝素酶 病理类型 子宫内膜不典型增生 

分 类 号：R737.33[医药卫生—肿瘤]