加味芍甘附子汤治疗阳虚寒凝型癌痛临床观察  

Clinical Observation on Modified Shaogan Fuzi Tang for Yang Deficiency and Cold Stagnation Type of Cancer Pain

作　　者：叶慧青[1] 杨劲松[1] 钟妙文[1] 潘萍[1] YE Huiqing YANG Jinsong ZHONG Miaowen PAN Ping

机构地区：[1]广州中医药大学附属新会中医院,广东江门529100

出　　处：《新中医》2017年第1期59-62,共4页New Chinese Medicine

摘　　要：目的:观察加味芍甘附子汤联合奥施康定治疗阳虚寒凝型癌痛的临床疗效。方法:将78例阳虚寒凝型癌痛患者随机分为2组,对照组38例采用奥施康定止痛治疗,治疗组40例在对照组治疗方案的基础上服用加味芍甘附子汤,比较2组患者临床疗效及生活质量改善等情况。结果:治疗组平均镇痛维持时间长于对照组,差异有统计学意义(P<0.01);治疗组奥施康定日均需用量少于对照组,差异有统计学意义(P<0.05);治疗组疗效总有效率92.5%,优于对照组81.6%,差异有统计学意义(P<0.05);治疗组Karnofsky评分总有效率90.0%,优于对照组65.8%,差异有统计学意义(P<0.05);治疗组发生便秘和恶心呕吐的毒副反应比对照组少,差异均有统计学意义(P<0.01,P<0.05)。结论:加味芍甘附子汤联合奥施康定在阳虚寒凝型癌痛患者治疗中能明显提高疗效和改善生存质量,减轻奥施康定的毒副反应。Objective：To observe the clinical effect of modified Shaogan Fuzi tang combined with oxycontin in treating patients with yang deficiency and cold stagnation type of cancer pain.Methods：Divided 78 patients with yang deficiency and cold stagnation type of cancer pain into two groups randomly.Thirty-eight cases in the control group received oxycontin for pain management,and 40 cases in the treatment group were additionally given modified Shaogan Fuzi tang.Compared the clinical effect and the improvement of quality of life between two groups.Results：The average duration of analgesia in the treatment group was longerthan that in the control group（P〈0.01）.Daily average requirement of oxycontin in the treatment group was less than that in the control group（P〈0.05）.The total effective rate of the treatment group was 92.5%,being superior to 81.6%of the control group（P〈0.05）.The total effective rate of Karnofsky score in the treatment group was 90.0%,being superior to65.8%of the control group（P〈0.05）.The treatment group had less toxic side effect such as constipation as well as nause and vomiting than the control group（P〈0.01,P〈0.05）.Conclusion：In the treatment for patients with yang deficiency and cold stagnation type of cancer pain,modified Shaogan Fuzi tang combined with oxycontin can significantly enhance the curative effect,improve quality of life and relieve toxic side effect of oxycontin.

关 键 词：癌痛 阳虚寒凝型 奥施康定 加味芍甘附子汤 镇痛时间 镇痛维持时间 KARNOFSKY评分 

分 类 号：R730.6[医药卫生—肿瘤]