金属蛋白酶8基因C-799T多态性位点与自发性早产遗传易感性的病例对照研究  

A case-control study on the MMP-8C-799T and susceptibility to spontaneous preterm birth and premature rupture of membranes

作　　者：杨晓[1] 彭薇[1] 朱丽娜[1] 张小爱[2] 王艳[1] 

机构地区：[1]中国人民解放军陆军总医院附属八一儿童医院发育生物学实验室,北京100700 [2]军事医学科学院微生物和流行病学研究所病原微生物生物安全重点实验室,北京100071

出　　处：《中国儿童保健杂志》2017年第2期112-116,共5页Chinese Journal of Child Health Care

基　　金：国家自然科学基金(81300527)

摘　　要：目的探讨金属蛋白酶8(MMP-8)基因C-799T多态性位点与自发性早产遗传易感性的关联性。方法病例组样本包括753例自发性早产(SPTB)新生儿,对照组包括681例足月新生儿。采用最新的Sequenom MassARRAY?SNP检测技术对MMP-8基因C-799T多态性位点进行SNP分型。结果与携带MMP-8基因C-799T多态性位点CC基因型的个体相比,携带至少一个-799T等位型(CT+TT基因型)的个体发生SPTB、合并PROM的SPTB(PPROM)以及轻度早产的风险显著降低。与携带至少一个C等位型(CC+CT基因型)的个体相比,TT基因型与不合并PROM的SPTB的患病风险的降低有临界的相关性。结论 MMP-8基因C-799T多态性位点可以影响SPTB的遗传易感性。Objective To investigate the association between the genetic polymorphisms of MMP-8C-799 Tand susceptibility to spontaneous preterm birth（SPTB）. Methods This case-control study enrolled 753 SPTB singleton neonates and 681 term neonates.Polymorphism was genotyped using Sequenom MassARRAY？SNP. Result Compared with the CC genotypes,MMP-8-799T-positive genotypes（CT＋TT genotypes）were significantly associated with a decreased susceptibility to SPTB and moderate SPTB.The-799T-positive genotypes（CT＋TT genotype）were also significantly associated with decreased SPTB susceptibility in preterm neonates with PROM.Comparing with the CC ＋ CT genotypes,-799 TT genotype was marginally associated with a decreased SPTB susceptibility in preterm neonates without PROM. ConclusionMMP-8C-799 Tcontributes to the SPTB susceptibility.

关 键 词：金属蛋白酶-8 自发性早产 胎膜早破 单核苷酸多态性 

分 类 号：R179[医药卫生—妇幼卫生保健]