Flecainide in Cadaveric Blood and Tissues  

作　　者：Vezzoli Sara Conti Adelaide Bernini Marzia 

机构地区：[1]Department of Legal Medicine, University of Brescia, Brescia 25123, ltaly

出　　处：《Journal of Pharmacy and Pharmacology》2017年第2期73-78,共6页药剂与药理学（英文版）

摘　　要：In this report, we described a death caused by a deliberate overdose of Flecainide acetate （Almarytm^（R））, an antiarrhythmic agent. The patient had taken a box of 20 Almarytm^（R） 100 mg tablets. The Flecainide concentration found in the post-mortem cardiac blood was 10.16 mg/L. This concentration could not have been determined by post-mortem diffusion of the drug from gastric residue because the patient was previously given activated carbon during the emergency procedure. In fact, in the peripheral blood, the Flecainide concentration was 8.64 mg/L, therefore, this concentration is overlapping with the concentration in the cardiac blood; the gastric content was negative at the screening of Flecainide, while the liver tissue concentration of Flecaiuide was 59.6 mg/L and the bile concentration was 128 mg/L. The brain tissue concentration of Flecainide was 4.19 mg/L. In this case, the cause of death, excluding that toxicity was depending on post-mortem gastric diffusion of the drug, because of the absorbing activity of the administered carbon at the recovery.

关 键 词：FLECAINIDE ANTIARRHYTHMIC cadaveric blood gastric content. 

分 类 号：R[医药卫生]