2型糖尿病对鼻咽癌患者预后的影响  

Relationship of Type 2 Diabetes with Prognosis of Patients with Nasopharyngeal Cancer

作　　者：谢国丰[1] 卢伟焰 曹卡加[3] 田允鸿[1] 邱慧芝[1] 王红梅[1] 张伟军[1] 

机构地区：[1]广州医科大学附属肿瘤医院,广东广州510095 [2]广东省中医医院,广东广州510120 [3]中山大学肿瘤防治中心,广东广州510060

出　　处：《中国肿瘤》2017年第1期63-67,共5页China Cancer

基　　金：广州市医药卫生科技一般引导项目(2015A011090)

摘　　要：[目的]观察2型糖尿病对鼻咽癌患者预后的影响。[方法]对2003年12月至2011年1月180例鼻咽癌患者资料进行回顾性分析。糖尿病组为2型糖尿病合并鼻咽癌病例共90例,对照组采用病例匹配方法 ,共纳入90例非糖尿病的鼻咽癌患者,应用Kaplan-Meier和Log-rank法计算和比较两组患者的5年总生存率、无复发生存率和无转移生存率。[结果]对照组和糖尿病组的5年总生存率分别是78.9%和68.9%(P>0.05);5年无转移生存率分别是89.7%和83.9%(P>0.05);5年无复发生存率分别为89.3%和78.2%(P<0.05)。COX风险回归模型多因素分析结果显示,性别是局部晚期鼻咽癌总生存的独立预后因素(P=0.039)。[结论 ]2型糖尿病使鼻咽癌的复发率升高,值得进一步研究。[Purpose] To investigate the relationship of type 2 diabetic mellitus（DM） with prognosis of patients with nasopharyngeal cancer（NPC）. [Methods] Clinical data of 180 patients with NPC admitted between December 2003 and January 2011 were retrospectively reviewed,including 90 patients with type 2 diabetic mellitus（DM group）,and 90 patients without type 2 diabetic mellitus（NDM group）. Then,Kaplan-Meier analysis and Log-rank test were used to calculate the distant metastasis-free survival（DMFS）,locoregional relapse-free survival（LRFS） and 5-year overall survival（OS） rate in two groups. [Results] The 5-year OS rate of NDM group and DM group were 78.9% and 68.9%,respectively（P〈0.05）,the 5-year DMFS rate were 89.7% and83.9%,respectively（P〈0.05）,and the 5-year LRFS rate were 89.3% and 78.2%,respectively（P〈0.05）. Multivariate analysis showed that gender was an independent prognostic factor for OS of NPC patients（P=0.039）. [Conclusion] The study shows that NPC patients with type 2 diabetes have a worse locoregional relapse-free survival than those without diabetes.

关 键 词：2型糖尿病 鼻咽癌 预后 

分 类 号：R739.63[医药卫生—肿瘤]