胃液α-抗胰蛋白酶检测在胃癌诊断中的意义  

Clinical Significance of Concentration Detection of Gastric Juice al-antitrypsin in Diagnosis of Gastric Cancer

作　　者：史向军[1] 黄新余[1] 汪昱[1] 郑起[1] 冯昌宁[1] 

机构地区：[1]上海市交通大学附属第六人民医院普外科,上海200233

出　　处：《医学临床研究》2017年第1期17-19,共3页Journal of Clinical Research

摘　　要：【目的】探讨胃液中α1-抗胰蛋白酶的检测对胃癌诊断的临床意义。【方法】选取2011年2月至2013年4月于本院行胃镜检查的114例胃癌（胃癌组）、43例胃部良性疾病（胃部良性疾病组）和25例健康人（对照组）为研究对象，采用ELISA法测定三组人员胃液中的α1-抗胰蛋白酶浓度，并进行统计学分析比较。【结果】胃癌组胃液中仪，-抗胰蛋白酶浓度[（1368．7±498．4）μg/dL]分别显著高于良性胃部疾病组[（345±96．5）μg/dL]和健康组[（31．2±17．3）μg／dL]，且差异有统计学意义（P〈0．05）；胃液α1-抗胰蛋白酶检测胃癌的敏感度、特异度、准确率分别为90．4％、89．7％、90．1％；Ⅲ-Ⅳ期胃癌患者胃液α1-抗胰蛋白酶浓度明显高于Ⅰ-Ⅱ期患者，差异具有统计学意义（P〈0．05）。【结论】检测胃液中α1-抗胰蛋白酶的浓度有助于提高胃癌的诊断准确率，有重要的临床应用价值，值得进一步研究及探讨。[ Objective] To explore the clinical significance of detection of gastric juice cq-antitrypsin in diagnosis of gastric cancer. [ Methods ] 114 patients with gastric cancer （gastric cancer group）, 43 patients with benign gas- tric diseases （benign gastric diseases group） and 25 healthy people （control group） who underwent upper gastrointes- tinal endoscopic examination in our hospital from February 2011 to April 2013 were selected as research subjects. The levels of concentration of gastric juice oh -antitrypsin of these three groups were examined respectively by ELISA. The experimental and clinical data were analyzed statistically. [ Results] The concentration of gastric juice oq-antitrypsin （1368.7 ±498.4） μg/dL in gastric cancer group was significantly higher than that in the benign gastric disease group （345 ± 96.5） μg/dL and the healthy group （31.2±17.3） μg/dL, and the difference was statistically significant （ P 〈 0.05 ） ; Gastric cancer sensitivity, specificity, accuracy of gastric juice oq-antitrypsin exams were 90. 4% , 89.7% and 90.1% ; the oh antitrypsin concentration of IU-Ⅳ gastric cancer patients was significantly higher than that of I - II patients, the difference was statistically significant （ P 〈 0.05 ）. [ Conclusion] The concentration detection of oh-antitrypsin in gastric juice can improve the accuracy in the diagnosis of gastric cancer and has great clinical value of further studying.

关 键 词：胃肿瘤/诊断 胃液 α-抗胰蛋白酶/代谢 

分 类 号：R735.2[医药卫生—肿瘤]