降钙素基因相关肽介导的药物药理学效应  

Pharmacological effects of drugs mediated by calcitonin gene-related peptide:a review

作　　者：尹优聪 李元建[1] 

机构地区：[1]中南大学药学院药理学系,湖南长沙410078

出　　处：《中国药理学与毒理学杂志》2017年第1期112-118,共7页Chinese Journal of Pharmacology and Toxicology

基　　金：国家自然科学基金项目(81273513)~~

摘　　要：降钙素基因相关肽(CGRP)是感觉神经纤维释放的主要神经递质,广泛分布于中枢和外周组织。在心血管系统,CGRP除了强效舒血管作用外,还能保护缺血心肌,减轻心脏重构。硝酸甘油的抗心绞痛作用及吴茱萸次碱的降压作用和减轻心脏重构作用均与促进CGRP合成与释放有关。在胃肠道,CGRP参与胃肠功能的调节并能减轻胃黏膜损伤,吴茱萸次碱、辣椒素及其衍生物通过促进CGRP的合成和释放对多种因素诱导的胃黏膜损伤具有保护作用。Calcitonin gene-related peptide（CGRP）, a predominant neurotransmitter in sensory nerves, is widely distributed in central and peripheral tissues. In the cardiovascular system, besides relaxing vascular smooth muscle, CGRP protects against ischemic myocardium while inhibiting cardiac remodeling. The pharmacological effects of nitroglycerin and rutaecarpine have proved to be associated with the increase in the synthesis and release of CGRP. In gastrointestinal tissues, CGRP participates in the regulation of gastrointestinal function and has protective effects on the gastric mucosa. Rutaecarpine, capsaicin and its derivatives can reduce gastric mucosa damage induced by a variety of factors by increasing synthesis and release of CGRP.

关 键 词：降钙素基因相关肽 硝酸甘油 吴茱萸次碱 辣椒素 沙坦类药物 

分 类 号：R96[医药卫生—药理学]