脑出血患者血肿和血浆中纤溶活性的相关性研究  

Study on the relationship between Hmatoma and Pasma finolytic activity in cerebral hemorrhage patients

作　　者：魏巍[1] 吕涌涛 陈兴旺[1] 孙良伟[1] 赵修敏[1] 郇英[1] 冯肖亚[1] WEI Wei LV Yongtao CHEN Xingwang et al(Department of Neurology, Shandong Traffic Hospital, Jinan 250031, China)

机构地区：[1]山东省交通医院,山东济南250031

出　　处：《中风与神经疾病杂志》2017年第1期59-62,共4页Journal of Apoplexy and Nervous Diseases

摘　　要：目的通过测定高血压性脑出血患者血肿内及血浆中纤溶酶原、D-二聚体的含量,以探讨颅内血肿纤溶活性及外周血纤溶活性的特点及相关性。方法选择2014年1月~2015年12月在山东省交通医院神经内科住院的行颅内血肿微创穿刺清除术的幕上高血压性脑出血患者20例。同时期选择20例健康查体者作对照组。留取手术组患者血肿及外周静脉血标本及对照组外周静脉血标本,采用酶联免疫吸附试验双抗体夹心法(ELISA)检测上清液纤溶酶原、D-二聚体水平。结果手术组患者外周血及血肿测得纤溶酶原比较,手术组外周血纤溶酶原均值(12.36±3.54)ng/ml,手术组血肿内纤溶酶原均值(14.99±3.70)ng/ml,两组间行独立样本t检验得t=2.293,P=0.027<0.05,两组间差异有统计学意义;手术组患者血肿及外周血纤溶酶原相关性检验具有正相关性(R=0.670,P=0.001<0.01);手术组患者血肿及外周血测得D-二聚体相关性检验无相关性(R=0.128,P=0.591>0.01)。结论高血压性脑出血患者血肿内存在纤溶酶原,血肿内平均纤溶酶原的含量要高于外周血,且两者之间存在相关性。Objective Through determination the plasminogen and D-dimer in hematoma and plasma of the hypertensive intracerebral hemorrhage patients,to explore the correlation of intracranial hematoma fibrinolytic activity and fibrinolytic activity in plasm of hypertensive intracerebral hemorrhagic patients. Methods： Chose 20 patients with hypertensive intracerebral hemorrhagic who were in Shandong traffic hospital and received intracranial hematoma micro invasive craniopuncture during January 2014 to December 2015. At the same time,a total of 20 patients were selected as health control group who did health examination. Extraction from the surgery group patients hematoma samples、plasma samples and control group plasma samples. The supernatant fluid plasminogen and D-dimer levels were measured with an enzyme-linked immunosorbent assay（ ELISA）. Result The levels of plasminogen in hematoma samples were significantly higher than those in plasma samples of the surgery group patients（ P〈0. 05）,the plasma samples of the surgery group patients average plasminogen was（ 12. 36 ± 3. 54） ng / ml,the hematoma samples of the surgery group patients average plasminogen was（ 14. 99± 3. 70） ng / ml. Plasminogen in hematoma with plasminogen in plasma had significant correlation（ R = 0. 670,P = 0. 001 0. 01）. There was no sufficient reason to think there was a correlation between D-dimer in hematoma with D-dimer in plasma（ R = 0. 128,P = 0. 591〉0. 01）. Conclusion The hematoma in hypertensive intracerebral hemorrhage patients was exist plasminogen,and the average plasminogen in hematoma were higher than those in the plasma（ P〈0. 05）,and there was a significant correlation between them.

关 键 词：脑出血 颅内血肿 纤溶酶原 D-二聚体 

分 类 号：R743.34[医药卫生—神经病学与精神病学]