叶酸/β-环糊精修饰的磁性纳米药物载体的合成及表征  

Preparation and Characterization of Folic acid/β-Cyclodextrins Modified Magnetic Nanoparticles Drug Carriers

作　　者：洪沙沙 李波[1] 周叶红[2] 梁文婷[2] 双少敏[1] 

机构地区：[1]山西大学化学化工学院,山西太原030006 [2]山西大学环境科学研究所,山西太原030006

出　　处：《山西大学学报（自然科学版）》2017年第1期130-136,共7页Journal of Shanxi University(Natural Science Edition)

基　　金：国家自然科学基金(21475080);山西省回国留学人员科研资助项目(2013-重点1)

摘　　要：采用共沉淀法在水相中合成表面修饰氨基的磁性纳米粒子(MNPs),进一步在其表面接枝叶酸(FA)修饰的β-环糊精衍生物(β-CDs),制得一种新型药物载体材料(FA-β-CDs-MNPs),并通过核磁共振光谱(1 H NMR)、红外光谱(FTIR)进行了结构表征。透射电镜(TEM)、X-射线衍射(XRD)、磁性能(VSM)分析表明:该纳米复合材料的尺寸为16nm左右,近似圆形且分散性能良好,用振动磁强计测得其具有超顺磁性,饱和磁化率为58emu/g,是潜在的肿瘤细胞靶向型药物载体材料。A novel MNPs-based nanoparticle drug delivery system（DDS）was assembled and characterized.MNPs were prepared according to chemical co-precipitation method.After amination with amino silane coupling agent,folic acid modifiedβ-CDs were grafted onto the surface of magnetic nanoparticles.The morphology and properties of obtained nanoparticles were characterized by nuclear magnetic resonance（1 H NMR）,Fourier transform infrared spectroscopy（FT-IR）,transmission electron microscopy（TEM）,Xray powder diffraction（XRD）,and vibrating sample magnetometer（VSM）.TEM images showed that the size of nanoparticles was about 16 nm.The FA-β-CD-MNPs exhibited relatively high saturation magnetization.These results suggested the newly developed magnetic hybrid nanomaterial has potential applications as the drug carrier.

关 键 词：磁性纳米 叶酸 Β-环糊精 靶向药物载体 

分 类 号：O621[理学—有机化学]