血清胃蛋白酶原联合Ca724在胃癌患者中的诊断及预后价值  

The diagnostic and prognostic value of serum pepsinogen combined with Ca724 in the patients with gastric cancer

作　　者：李恩就[1] 胡菂菂[1] 龚志军[1] 卿笃桔[1] 刘虹[1] 黎飞[1] 

机构地区：[1]江门市中心医院,江门529000

出　　处：《实用肿瘤学杂志》2017年第1期18-22,共5页Practical Oncology Journal

基　　金：江门市医药卫生科学技术研究项目(201601002000357)

摘　　要：目的探讨联合血清胃蛋白酶原及糖类抗原724(Ca724)检查在胃癌诊断及预后评价中的应用价值。方法以120例疑似胃癌患者作为观察对象,所有患者均接受血清胃蛋白酶原Ⅰ(PGⅠ)、血清胃蛋白酶原Ⅱ(PGⅡ)、Ca724及胃镜检查,以胃镜下活检病理检查结果作为确诊标准,分析PGⅠ/PGⅡ(PGR)、Ca724及PGR联合Ca724检查对胃癌的诊断价值。结果所有观察者中,共有92例确诊为胃癌。PGR联合Ca724检查的诊断灵敏性及准确性均高于PGR检查及Ca724检查,而诊断特异性低于PGR检查及Ca724检查。同时,PGR检查、Ca724检查及PGR联合Ca724检查对于胃癌均有一定的诊断价值,而PGR联合Ca724检查的诊断价值高于PGR检查及Ca724检查(P<0.05)。此外,不同病理分期间PGR及Ca724存在统计学差异,以Ⅳ期组PGR最低,Ca724最高(P<0.05)。结论联合血清胃蛋白酶原及Ca724检查在胃癌的诊断及预后评价中具有明确的应用价值。Objective To analyze the diagnostic and prognostic value of serum pepsinogen combine with Ca724 in the patients with gastric cancer. Methods One hundred and twenty patients with suspected gastric cancer were severed as research object. All patients were accepted on serum pepsinogen Ⅰ （ PG Ⅰ ） , serum pep-sinogen Ⅱ （ PG Ⅱ ） , Ca724 and gastroscopy. As confirmed by gastroscope biopsy under pathological findings standards,we analyzed the diagnostic and prognostic value of PG Ⅰ /PG Ⅱ （PGR） ,Ca724 and PGR combined with Ca724 in the patients with gastric cancer. Results All the observers,92 patients were diagnosed with stomach cancer. The diagnostic sensitivity and accuracy of PGR combined with Ca724 were higher than PGR and Ca724, and specificity was lower than PGR and Ca724. At the same time,there was diagnostic value of PGR,Ca724 and PGR combined with Ca724 in gastric cancer diagnostic （P 〈0. 05） ,and the diagnostic value of PGR combined with Ca724 was higher than PGR check and Ca724. In addition,during the different pathological,there were sta-tistically significant differences of PGR and Ca724,the PGR in Ⅳ group was lowest,the Ca724 in the Ⅳ group was highest（P 〈 0. 05）. Conclusion Combined serum pepsinogen and Ca724 in the diagnosis and differential diagnosis of gastric cancer have a definite application value in the assessment of prognosis.

关 键 词：血清胃蛋白酶原 糖类抗原724 胃癌 诊断价值 预后 

分 类 号：R735.2[医药卫生—肿瘤]