乳腺癌肝转移机制研究进展  

Mechanisms involved in liver metastasis of breast cancer

作　　者：李博[1] 陈雪松[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院乳腺内科,哈尔滨150081

出　　处：《实用肿瘤学杂志》2017年第1期48-52,共5页Practical Oncology Journal

基　　金：国家自然科学基金(81573001);黑龙江省科技厅项目(LC201438)

摘　　要：肝脏是乳腺癌常见的转移部位。乳腺癌肝转移的过程包括多个步骤,涉及乳腺癌细胞和肝脏微环境中的多种因素。在本文中,我们综述了与乳腺癌肝转移相关的分子(包括连接蛋白类、蛋白激酶类、miRNAs)、信号转导通路(包括CXCL12-CXCR4轴、Wnt/β-catenin信号通路、AF1q/FCF7/CD4调节轴、层黏连蛋白受体/Akt/ERK信号通路、瘦素/ERK/IL-8信号通路)以及肝脏微环境中的影响因素(包括缺氧诱导因子、肿瘤相关成纤维细胞、脂肪基质干细胞、金属蛋白酶、选择性配体、炎性细胞免疫浸润)。Liver is the common metastatic site of breast cancer. The process of liver metastasis consists of multiple steps and involves various factors from breast cancer cells and the liver micro - environment. In this re-view, we reviewed the molecular（ including the connection of proteins,protein kinases,miRNAs） ,signal transduc-tion pathways（ including CXCL12 - CXCR4 axis, Wnt/beta -catenin signaling pathway, AF1 q/TCF7/CD44 regu- latory axis,laminin receptor/Akt/ERK signaling pathway,leptin/ERK/IL - 8 signaling pathway） and the influen-cing factors（including hypoxia inducible factors, tumor - associated fibroblasts, adipose tissue matrix stem cells, metalloproteinases,selective ligands,inflammatory cell infiltration）associated with the liver micro-environment in breast cancer.

关 键 词：乳腺癌 肝转移 微环境 

分 类 号：R737.9[医药卫生—肿瘤]