恒清汤治疗椎-基底动脉供血不足性眩晕的临床研究  

Clinical Observation on Hengqing Decoction in the Treatment of Vertebrobasilar Insufficiency-Associated Vertigo

作　　者：孟胜喜[1] 霍清萍[1] 王兵[1] 彭文波[1] 王宇新[1] 梁芳[1] 汪天湛[1] 

机构地区：[1]上海交通大学附属第六人民医院,上海200233

出　　处：《中西医结合心脑血管病杂志》2017年第1期17-20,共4页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：上海市科委中医类引导项目(No.15401933300)

摘　　要：目的研究恒清汤治疗椎-基底动脉供血不足(VBI)性眩晕的临床疗效及其效应机制。方法将126例VBI病人随机分为治疗组(64例)和对照组(62例)。对照组在常规治疗的基础上加服盐酸氟桂利嗪胶囊(西比灵),治疗组在常规治疗的基础上加服恒清汤。两组均以14d为1个疗程,连续2个疗程后观察疗效。治疗前后两组采用经颅多普勒超声(TCD)分别检测椎动脉(VA)、基底动脉(BA)的收缩峰血流速度(Vp)、舒张末期血流速度(Vd)、平均血流速度(Vm),并检测血液流变学的变化。结果治疗组、对照组的总有效率分别为84.38%、70.97%,治疗组优于对照组(P<0.05);治疗组治疗后病人Vp、Vd和Vm较治疗前均显著提高(P<0.01),对照组治疗后病人仅Vd、Vm较治疗前有所提高(P<0.05);两组治疗后比较,治疗组Vp、Vd、Vm均高于对照组(P<0.05或P<0.01)。治疗组治疗后较治疗前血液流变学各指标均有明显改善(P<0.01),对照组治疗前后比较差异无统计学意义(P>0.05);两组治疗后比较,治疗组血液流变学改善优于对照组(P<0.05或P<0.01)。结论恒清汤对VBI性眩晕具有显著的临床疗效,其效应机制可能与提高Vp、Vd和Vm,改善病人的血液流变学有关。Objective To observe the therapeutic effect and mechanism of Hengqing decoction（HQD）in the treatment of vertebrobasilar insufficiency（VBI）-associated vertigo.Methods One hundred and twenty-six patients with VBI were randomly divided into two groups：control group（n =62）treated with routine treatment,and treatment group（n =64）treated with HQD plus routine treatment for 14 days.The therapeutic effect was observed after two treatment courses.The peak-systolic velocity（Vp）,end-diastolic velocity（Vd）and mean velocity（Vm）of vertebral artery（VA）and basilar artery（BA）were detected with transcranial doppler（TCD）before and after treatment.The change of hemorhcology was also detected.Results The total effective rate was 84.38%and 70.97%in treatment group and control group respectively,with a significant difference between two groups（P〈0.05）.The Vp,Vd and Vm were significantly increased in treatment group after treatment（P〈0.05 or P〈0.01）.The Vp,Vd and Vm in the treatment group were significantly higher than those in the control group after treatment（P〈0.05 or P〈0.01）.The hemorheological indexes were significantly improved in the treatment group after treatment（P〈0.01）.There was no significant difference in hemorhcological indexes between before and after treatment in control group（P〉0.05）.Compared with the control group,the hemorhcological indexes were significantly improved in treatment group after treatment（P〈0.05 or P〈0.01）.Conclusion HQD is effective for VBl-associated vertigo.The underlying mechanism may be associated with increasing Vp,Vd and Vm and improving hemorhcology.

关 键 词：椎-基底动脉供血不足性眩晕 恒清汤 盐酸氟桂利嗪胶囊 经颅多普勒超声 血痹 

分 类 号：R743.3[医药卫生—神经病学与精神病学]