兰索拉唑治疗消化道溃疡上消化道出血的综合疗效观察  

Observation of comprehensive curative effect by lansoprazole in the treatment of peptic ulcer upper gastrointestinal hemorrhage

作　　者：常旭[1] 

机构地区：[1]铁岭市中心医院消化内科,112608

出　　处：《中国实用医药》2016年第34期129-130,共2页China Practical Medicine

摘　　要：目的观察兰索拉唑治疗消化道溃疡上消化道出血的综合临床疗效。方法 164例消化道溃疡上消化道出血患者,随机分为对照组和观察组,每组82例。对照组给予法莫替丁联合克拉霉素胶囊,阿莫西林的三联法治疗;观察组给予兰索拉唑联合克拉霉素胶囊,阿莫西林的三联法治疗。两组疗程均为8周。治疗后观察两组患者的临床疗效、临床症状缓解情况、止血时间、幽门螺杆菌（Hp）的根除率及不良反应。结果观察组止血时间为（5.34±0.65）d,Hp根除率为85.4%;对照组止血时间为（7.61±1.06）d,Hp根除率为70.7%;观察组止血时间及Hp的根除率均明显优于对照组（P〈0.05）。观察组治疗总有效率为93.90%,明显高于对照组的78.05%,差异具有统计学意义（P〈0.05）。两组患者用药期间的不良反应均较轻微,停药后3~4 d症状消失。两组不良反应发生率比较差异无统计学意义（P〉0.05）。结论应用兰索拉唑治疗消化道溃疡上消化道出血,止血时间短,不良反应少,疗效显著,值得临床广泛推广。Objective To observe clinical effect by lansoprazole in the treatment of peptic ulcer upper gastrointestinal hemorrhage. Methods A total of 164 patients with peptic ulcer upper gastrointestinal hemorrhage were randomly divided into control group and observation group, with 82 cases in each group. The control group received famotidine combined with clarithromycin capsules and amoxicillin for triple therapy. The observation group received lansoprazole combined with clarithromycin capsules and amoxicillin for triple therapy. Treatment in both groups lasted for 8 weeks. Observation was made on clinical effects, clinical symptoms relief condition, hemostasis time, helicobacter pylori（Hp） eradication rate and adverse reactions in both groups after treatment. Results The observation group had mean hemostasis time as（5.34±0.65） d and Hp eradication rate as 85.4%. The control group had mean hemostasis time as（7.61±1.06） d and Hp eradication rate as 70.7%. The observation group had obviously better hemostasis time and Hp eradication rate than the control group（P〈0.05）. The observation group had much higher total effective rate as 93.90% than 78.05% in the control group, and the difference had statistical significance（P〈0.05）. Both groups had mild adverse reactions during drug administration, and their symptoms relieved in 3~4 d after drug withdrawal. There was no statistically significant difference of adverse reactions rate between the two groups（P〉0.05）. Conclusion Implement of lansoprazole in treating peptic ulcer upper gastrointestinal hemorrhage shows short hemostasis time, few adverse reactions and excellent curative effect. This method is worth widely clinical promotion.

关 键 词：兰索拉唑 消化道溃疡 法莫替丁 上消化道出血 

分 类 号：R573[医药卫生—消化系统]