应用新西兰白兔验证可降解网状微孔球囊联合钙盐骨水泥治疗骨折的作用  

Biodegradable Mesh-like Microporous Balloon Combined with Calcium Phosphate Bone Cement for the Treatment of Fracture: A New Zealand Rabbit Study

作　　者：吴建英[1] 刘贵省 刘训伟[3] 

机构地区：[1]济南军区总医院实验诊断科,济南250031 [2]郓城县人民医院放射科,郓城274700 [3]济南军区总医院医学影像科,济南250031

出　　处：《实验动物科学》2016年第6期11-15,共5页Laboratory Animal Science

基　　金：国家高技术研究发展计划(863计划)资助(2013AA032203);国家自然科学基金资助(51073173);济南军区总医院院长基金资助(2012ZX002)

摘　　要：目的通过观察新西兰白兔股骨内植入材料的降解及血液指标的变化验证可降解网状微孔球囊联合钙盐骨水泥治疗骨折的作用。方法根据植入物不同分为实验组(植入可降解网状微孔球囊及钙盐骨水泥)和对照组(植入钙盐骨水泥),对术前、术后1,3,6个月的血液指标进行组间及组内比较,并通过影像学及病理学对植入物降解和骨组织生长匹配情况进行对比分析。结果实验组和对照组血液指标无明显改变;在体内无明显免疫反应;骨组织均可伸入到骨水泥间隙内,取代降解的骨水泥,形成规则的骨小梁结构;实验组骨小梁较对照组粗大致密、分布规则。结论通过新西兰白兔验证了可降解网状微孔球囊联合钙盐骨水泥对活体无明显免疫反应,并利于骨折的修复愈合。Objective To investigate the degaration of femoral implant materials and blood index changes to identify the therapeutic effect of biodegradable mesh-like microporous balloon and calcium phosphate bone cement for the treatment of bone fracture in New Zealand rabbit. Method The rabbit models were randomized into two groups ：the experimental group with biodegradable mesh-like microporous balloon and calcium phosphate bone cement and the control group only with calcium phosphate bone cement. Clinical parameters such as blood cell count were examined and compared with intra-group and extra-group at pre-operation,and 1, 3 and 6 months after operation. Moreover, the degradation states of implant and the growth situation of bone in the two groups were compared according to the imaging data. Result No statistical significance for blood cell counts was found between pre- and post-operation or between two groups. The materials in the two groups had favorable biocompatibility without obvious immunological response. Bone tissue can grow into bone cement gaps, to replace the degradation of bone cement and formation rules of trabecular bone structure. The trabecular structure of experimental group were bulky density, distribution rules than control group. Conclusion The research verified that it has no obvious immune response while putting the degradable mesh porous balloon calcium salt into living bone cement, and is conducive to the restoration of fracture healing in New Zealand rabbit.

关 键 词：新西兰白兔 可降解材料 骨水泥 骨折 

分 类 号：R-332[医药卫生]