干细胞标志物CD133与胃癌临床特征的相关性研究  

Correlation research between stem cell marker CD133 and clinical features of gastric cancer patients

作　　者：鲁明[1] 付波[1] 马翔[1] 吴冬冬[1] 赵庆洪[1] 

机构地区：[1]南京医科大学第二附属医院普外科,江苏南京210011

出　　处：《中国医药科学》2016年第21期22-28,共7页China Medicine And Pharmacy

摘　　要：目的探讨CD133蛋白表达与胃癌患者临床特征以及预后之间的关系。方法使用免疫组化染色方法检测我院118例胃癌患者手术切除的病灶组织中CD133表达情况,并检索相关数据库对已报道的CD133表达与胃癌临床特征的研究做系统性荟萃分析,进一步验证我们的结果。结果免疫组化结果显示胃癌患者CD133蛋白表达阳性率为28.81%（34例/118例）。CD133表达与患者年龄、性别、肿瘤直径、分化程度、Lauren’s分型无关（P〉0.05）;但与胃癌患者肿瘤的浸润深度、淋巴结转移及TNM分期明显相关（P〈0.05）。Meta分析结果显示胃癌肿瘤浸润越深（OR=0.36,95%CI=0.26~0.49,P〈0.0001）;有淋巴结转移（OR=0.36,95%CI=0.26~0.50,P〈0.0001）;以及TNM分期越高（OR=0.32,95%CI=0.24~0.42,P〈0.0001）,CD133蛋白阳性表达率越高。并且CD133阳性表达提示胃癌患者预后不良（HR=2.21,95%CI=1.52~3.22）。结论 CD133表达与胃癌浸润深度,淋巴转移,临床分期以及预后显著相关,也许能够作为未来胃癌治疗的新的分子靶点。Objective To explore the association between the expression of CD133 and the clinical features of gastric cancer patients. Methods The expression of CD133 protein in gastric cancer tissues of 118 patients were detected by immunohistochemical（ICH） staining. A meta-analysis was performed to further validate the correlation of CD133 expression with the clinical characteristics of gastric cancer patients. Results The results of ICH indicated that the positive expression rate of CD133 in gastric cancer tissues was 28.81%（34/118）. The expression of CD133 was not associated with the age, sex, tumor diameter, differentiation and Lauren＇ s types（P〉0.05）, but it was correlated with depth of invasion, lymphatic metastasis and clinical stages（P〈0.05）. In addition, in our meta-analysis, we found the expression rate of CD133 was higher in T3,T4 of invasion depth（OR=0.36, 95%CI=0.26–0.49, P〈0.0001）, and it was positive of lymphatic metastasis（OR=0.36, 95%CI=0.26–0.50, P〈0.0001） and III, IV of clinical stage（OR=0.32, 95%CI=0.24–0.42, P〈0.0001）. Positive expression of CD133 was related to worse prognosis（HR=2.21, 95%CI=1.52-3.22）. Conclusion The expression of CD133 was associated with depth of invasion, lymphatic metastasis, clinical stages and poor outcome of gastric cancer. CD133 may act as a new molecular target for treatment of gastric cancer in the future.

关 键 词：CD133 肿瘤干细胞 胃癌 免疫组化 荟萃分析 

分 类 号：R735.2[医药卫生—肿瘤]