腺苷酸环化酶相关蛋白1在食管鳞形细胞癌中的表达及意义  

Expression and Significance of Cyclase-associated Protein 1(CAP1)in Esophageal Squamous Cell Carcinoma

作　　者：吴建华[1] 姚秀芳[1] 钱粒 章建国[2] 

机构地区：[1]如东县人民医院病理科,江苏226400 [2]南通大学附属医院病理科

出　　处：《交通医学》2016年第5期430-433,共4页Medical Journal of Communications

摘　　要：目的:探讨腺苷酸环化酶相关蛋白1(cyclase-associated Protein 1,CAP1)在食管鳞形细胞癌(esophageal squamous cell carcinoma,ESCC)组织中的表达及临床病理学意义。方法:采用免疫组织化学方法(Envision法)和Western blot方法检测CAP1在98例ESCC石蜡标本和10例新鲜ESCC组织标本中的表达,分析与ESCC临床病理因素的关系。结果:免疫组化结果显示CAP1在98例ESCC组织细胞中阳性表达率为45.9%(45/98),CAP1的表达与淋巴结转移和患者的生存率有相关性(P<0.05),与患者年龄、性别、组织学分级、肿瘤大小和浸润深度无相关性。Western blot显示伴有淋巴结转移的ESCC中CAP1表达明显高于不伴有淋巴结转移的ESCC。结论:CAP1的高表达可能参与ESCC的侵袭和转移,CAP1高表达可能是预后不良的指标。Objective：To investigate the clinicopathological significance of expression of Cyclase-associated Protein1（CAP1） in esophageal cell carcinoma（ESCC）. Methods：The CAP1 protein was detected by immunohistochemistry in 98 cases of ESCC,and by western blot assay in 10 cases of ESCC respectively. Results：The CAP1 positive rate was 45.9%（45/98）in 98 cases of ESCC, and negatively associated with E-cadherin,and positively associated with lymph node metastase and poor survival. There were no relationships between CAP1 and age, gender,pathologic grading, tumor size and depth.Western blot assay show that CAP1 levels in ESCC tissues without lymph node metastases were significantly lower than those with lymph node metastases,and E-cadherin levels were on the contrary. Conclusions：CAP1 may be involved in the metastasis of esophageal squamous cell carcinoma, and the elevated levels of CAP 1 expression may indicate a poor prognosis.

关 键 词：食管鳞形细胞癌 腺苷酸环化酶1 免疫组织化学 

分 类 号：R735.1[医药卫生—肿瘤]