白藜芦醇诱导肿瘤细胞凋亡研究进展  

A Progress on the Effects of Resveratrol on Tumor Cells

作　　者：韩军军[1] 张玉明[2] 潘学峰[1,3] 谢松[2] 段斐[1] 李红权[1] Han Junjun Zhang Yuming Pan Xuefeng Xie Song Duan Fei Li Hongquan(School of Medicine, Hebei University, Baoding 071002, China School of Life Sciences, Hebei University, Baoding 071002, China School of life Sciences, Beijing Institute of Technology, Beijing 100081, China)

机构地区：[1]河北大学医学院,保定071000 [2]河北大学生命科学学院,保定071002 [3]北京理工大学生命科学院,北京100081

出　　处：《世界科学技术-中医药现代化》2016年第12期2176-2181,共6页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：河北省自然科学基金委面上项目(H2015201131):基于iNKT细胞类核苷免疫调节剂CH干预型糖尿病的机制研究;负责人;陈冬志;河北省自然科学基金委面上项目(C2015201165):日本沼虾硫氰酸生成酶基因的免疫功能研究;负责人;谢松;河北大学医学学科专项资金建设项目(2012A2004):环境中铬对生殖细胞的毒性及微生物对其转化作用;负责人:李红权

摘　　要：白藜芦醇是一种具有抗氧化、抗肿瘤、诱导细胞凋亡等生物活性的天然多酚类化合物。本文对近年来白藜芦醇诱导人宫颈癌He La细胞、白血病细胞、肝癌细胞和胃癌细胞等细胞凋亡方面的研究进展进行了分析和总结,并重点探讨了白藜芦醇诱导肿瘤细胞凋亡的分子机制,总结了白藜芦醇通过阻滞细胞周期、调节相关基因及蛋白表达和线粒体诱导细胞凋亡途径的研究现状,以及白藜芦醇作为肿瘤药物在临床研究中的潜在应用前景。Resveratrol is a natural polyphenolic substance with a variety of bioactivities, such as anti-oxidation, anti-tumor and apoptosis induction. This paper summarized the recent research progress of resveratrol induced cancerous cell apoptosis, including human cervical cancer He La cells, leukemia cells, hepatoma cells and gastric cancer cells, and analyzed the molecular mechanism behind resveratrol-induced cell apoptosis in tumor. In addition, resveratrol was investigated by blocking the cell cycle, regulating the expressions of related genes and proteins and mitochondria-induced apoptosis pathways as a potential application of cancer drugs to clinical researches.

关 键 词：白藜芦醇 肿瘤 抗氧化 多酚 细胞凋亡 

分 类 号：R285.5[医药卫生—中药学]