复方甘草酸苷对慢性乙型肝炎患者肝功能、肝纤维化指标及炎症因子的影响  

Influence of compound glycyrrhizin on liver functions,liver fibrosis indexes and inflammatory factors of patients with chronic hepatitis B

作　　者：彭福江[1] 张天晓[2] 袁美蓉[3] PENG Fu-jiang ZHANG Tian-xiao YUAN Mei-rong(Department of Infectious Disease Department of Internal Emergency Department of Internal Medicine, Dongguan Chang fin Hospital, Dongguan City 523850, Guangdong Province, China)

机构地区：[1]东莞市长安医院感染内科,广东东莞523850 [2]东莞市长安医院急诊内科,广东东莞523850 [3]东莞市长安医院内科门诊,广东东莞523850

出　　处：《海南医学院学报》2017年第4期485-488,492,共5页Journal of Hainan Medical University

基　　金：基金项目:广东省卫生厅(B2014020)~~

摘　　要：目的:探讨复方甘草酸苷对慢性乙型肝炎患者肝功能、肝纤维化指标及炎症因子的影响。方法:选取2015年1月~2016年6月我院收治的慢性乙型肝炎患者96例作为研究对象,随机分为观察组48例和对照组48例,两组均接受常规保肝药物治疗,观察组在常规治疗的基础上给予复方甘草酸苷注射液,比较观察两组治疗前后肝功能指标、肝纤维化指标及炎症因子的变化。结果:两组治疗前谷草转氨酶(AST)、谷丙转氨酶(ALT)、白蛋白(ALB)、总胆红素(TBIL)水平无明显差异(P>0.05);治疗后,两组AST、ALT、TBIL均显著降低,ALB均显著升高,与治疗前比较差异明显(P<0.05);治疗后,观察组ALT、AST、TBIL水平分别为(29.53±9.44)U/L、(32.36±10.93)U/L、(10.12±3.22)μmol/L,均显著低于对照组,观察组ALB水平为(43.57±12.42)g/L,显著高于对照组ALB水平(P<0.05)。治疗前,两组透明质酸(HA)、层黏连蛋白(LN)、Ⅳ型胶原(IV-C)以及Ⅲ型前胶原(PCⅢ)水平无统计学差异(P>0.05);治疗后,两组HA、LN、IV-C、PCⅢ均显著降低,与治疗前比较差异明显(P<0.05);治疗后,观察组的HA、LN、IV-C、PCⅢ水平分别为(97.33±31.75)μg/L、(77.52±23.72)μg/L、(82.92±24.55)μg/L、(15.33±5.11)μg/L,均显著低于对照组(P<0.05)。治疗前,两组白细胞介素-2(IL-2)、IL-6、肿瘤坏死因子-α(TNF-α)水平差异不明显(P>0.05);治疗后,两组IL-2均显著升高,IL-6、TNF-α均显著降低,差异均有显著性(P<0.05);治疗后,观察组IL-2水平为(131.48±30.63)U/mL,高于对照组IL-2水平,观察组IL-6、TNF-α水平分别为(45.23±16.45)μg/L、(41.75±17.53)ng/L,低于对照组IL-6、TNF-α水平,差异有显著性(P<0.05)。结论:复方甘草酸苷可有效减轻慢性乙型肝炎患者的肝纤维化及炎症反应,进而改善肝功能。Objective：To investigate influence of Compound Glycyrrhizin on liver functions,liver fibrosis indexes and inflammatory factors of patients with chronic hepatitis B.Methods：A total of 96 cases of patients with chronic hepatitis B trea-ted in our hospital from Jan 2015 to Jun 2016 were selected as subjects,and randomly divided to be 48 cases of observation group and 48 cases of control group.Patients in both of the two groups were received routine liver protecting drug treatment.For observation group,Compound Glycyrrhizin injection was given on the basis of routine treatment.Variations of liver function indexes,liver fibrosis indexes and inflammatory factors between the two groups before and after treatment were compared and observed.Results：No obvious difference showed on AST,ALT,ALB TBIL levels between two groups of patients before treatment（P〉0.05）;After treatment,AST,ALT,TBIL in two groups of patients were significantly decreased,ALB were significantly increased.Significant difference showed comparing with prior treatment（P〈0.05）;After treatment,AST,ALT and TBIL levels in observation group were（29.53±9.44）U/L,（32.36±10.93）U/L and（10.12±3.22）μmol/L,which were significantly lower than in control group.ALB levels in observation group were（43.57±12.42）g/L,which were significantly higher than ALB levels in control group（P〉0.05）.Before treatment,no statistical difference showed on HA,LN,Ⅳ-C and PCⅢlevels between two groups of patients（P〉0.05）.After treatment,HA,LN,IV-C and PCⅢin two groups of patients were significantly decreased,which showed significant difference comparing with prior treatment（P〈0.05）;After treatment,HA,LN,IV-C and PC Ⅲ levels in observation group were（97.33 ± 31.75）μg/L,（77.52 ± 23.72）μg/L,（82.92±24.55）μg/L,（15.33±5.11）μg/L,which were significantly lower than in control group（P〈0.05）.Before treatment,no significant difference showed on IL-2,IL-6and TNF-αlevels between two groups of patients（P〈0.05�

关 键 词：复方甘草酸苷 慢性乙型肝炎 肝功能 肝纤维化指标 炎症因子 

分 类 号：R575.11[医药卫生—消化系统]