皮下植入式胸腔港在新西兰大白兔胸腔灌注中的应用价值分析  

Value analysis of subcutaneous implantable pleural port in the application of the New Zealand white rabbit treated with pleural perfusion

作　　者：刘杰[1] 鲁金乐[1] 李卫[1] 屈会云[1] 史晓熠 王庆海[1] 马新杰[1] 何明[2] 

机构地区：[1]沧州中西医结合医院头颈胸外科,河北沧州061001 [2]河北医科大学第四医院胸五科,河北石家庄050011

出　　处：《临床和实验医学杂志》2017年第4期326-329,共4页Journal of Clinical and Experimental Medicine

摘　　要：目的分析皮下植入式胸腔港在新西兰大白兔胸腔灌注中的应用价值。方法将48只雄性新西兰大白兔随机分为三组,每组16只。A组采用皮下植入式胸腔港留置胸腔,生理盐水灌注;B组采用中心静脉管留置胸腔,生理盐水灌注;C组采用皮下植入式胸腔港留置胸腔,顺铂灌注。观察新西兰大白兔的机体健康状况、感染率、通畅性、植入物稳定性和胸膜粘连程度。结果 A组白兔治疗前后的血气化验结果差异无统计学意义(P>0.05),且该组白兔的肺泡结构清晰。A组与B组比较,两组均未发生堵管现象,A组大白兔的感染率显著低于B组,且植入稳定性显著高于B组(P<0.05)。A组与C组比较,A组白兔的粘连程度显著低于C组(P<0.05)。结论皮下植入式胸腔港应用于新西兰大白兔胸腔灌注中感染率低,没有明显的全身炎症反应,不产生胸膜粘连作用,不影响肺功能,其操作安全微创,效果肯定,可用于长期给药和引流。Objective To analyze application value of subcutaneous implantable pleural port in the New Zealand white rabbit treated with pleural perfusion. Methods The 48 New Zealand male white rabbit were selected and randomly divided into three groups with 16 rabbits in each group,the rabbits＇ chests were treated with implantable pleural port and perfuse physiological saline in group A. The rabbits＇ chests were treated with central venous tube and perfuse physiological saline in group B. The rabbits＇ chests were treated with implantable pleural port and perfuse cisplatin in group C. Then health status,infection rates,unobstructed,implant stability and pleural adhesion degree of New Zealand white rabbit were observed. Results There was no statistically significant difference of blood gas test results before and after treatment（ P〈0. 05） in group A and the white rabbit alveolar structure of group A was clear. Comparing group A with B,pipe blocking was noticed in both groups. The infection rate in white rabbit of group A was significantly lower than in group B,and implant stability in group A was significantly higher than in group B（P〈0. 05）. Comparing group A with C,pleural adhesion degree in group A was significantly lower than in group C（ P〈0. 05）. Conclusion Subcutaneous implantable pleural port in the application of the New Zealand white rabbit treated with pleural perfusion has low infection rate and no obvious systemic inflammatory response. Subcutaneous implantable pleural port do not produce pleural adhesion effect and do not affect the lung function,and the operation is safety and minimally invasive,the effect is sure and can be used for dosing and drainage for a long time.

关 键 词：新西兰大白兔 皮下植入式胸腔港 胸腔灌注 中心静脉管 

分 类 号：R730.5[医药卫生—肿瘤]