上消化道疾病与呼吸道等疾病幽门螺旋杆菌抗体对比研究  

Comparative study on the detection of Helicobacter pylori in patients with upper gastrointestinal diseases and respiratory diseases

作　　者：吴友根[1] 王平[1] 杨忠[1] 陈大勇[1] 刘红兵[1] 罗菊华[1] 李朝金[1] 唐兴俊[1] WU You-gen WANG Ping YANG Zhong CHEN Da-yong LIU Hong-bing LUO Ju-hua LI Chao jin TANG Xing-jun(Department of Infectious Diseases ,Workers＇ Hospital of China 19th Metallurgical Corporation ,Panzhihua Sichuan 617023 ,China)

机构地区：[1]中国十九冶集团有限公司职工医院,四川攀枝花617023

出　　处：《中国冶金工业医学杂志》2017年第1期9-10,共2页Chinese Medical Journal of Metallurgical industry

基　　金：攀枝花市适宜卫生技术研究(项目编号:2015CY-S-29)

摘　　要：目的探讨幽门螺旋杆菌(Hp)感染患者血清中抗体与各种疾病的关系。方法利用蛋白芯片技术检测7组研究对象共2940例,其中慢性胃炎1693例、消化性溃疡383例、胃肠道肿瘤82例、其他肿瘤249例、肝脏疾病195例、HIV或AIDS 109例、以及对照组肺结核患者(TB)229例。血清Hp的3种抗体:CagA抗体、VacA抗体和Ure抗体。结果慢性胃炎组的3种抗体的阳性率分别为1.4%、4.4%和24.5%;消化性溃疡组为1.3%、4.4%和33.9%;消化道肿瘤组为7.3%、15.8%和28.0%;其他肿瘤组为4.4%、10.8%和31.7%;肝脏疾病为1.5%、6.1%和33.3%;HIV/AIDS组为0.9%、8.2%和34.8%;对照组(TB)分别为1.3%、5.2%和24.0%。胃肠道肿瘤组、其它肿瘤组抗体阳性率与对照组比较差异具有统计学意义(P<0.05)。其余各组与对照组比较抗体阳性率差异无统计学意义(P>0.05)。结论提示不同抗体的存在可能与肿瘤有一定的关系,但3种抗体与消化道、呼吸道、肝脏等疾病无甄别关系。所有疾病抗体阳性率均低于50%,用于诊断幽门螺旋杆菌感染价值不大。Objective To study the significance of Helicobaeter pylori（Hp） antibodies in patients infected by the Hp. Methods The technology of protein chip was used to detect 3 kinds of Hp antibodies（anti-CagA, anti-VacA and anti-UreA） in 2940 patients,including 1693 cases of chronic gastritis, 383 peptic ulcer, 82 gastrointestinal tract carcinoma, 249 cases of other tumors, 195 cases of liver diseases, 109 cases of HIV/AIDS and 229 cases of tuberculosis in control group. Results The positive rate of the three kinds of antibodies were 1.4 %,4.4 % ,24.5 % respectively in chronic gastritis group; 1.3% ,4.4% ,33.9% respectively in peptic ulcer group; 7. 3%,15.8% ,28.0% in peptic gastrointestinal tract carcinoma group; 4.4% ,10. 8% ,31.7% respectively in other tumor group; 1.5%, 6.1%, 33.3% in liver diseases group and 0.9% ,8.2%, 34.8% respectively in HIV/AIDS group; 1.3%, 5.2% and 24.0% respectively in control group （TB）. The positive rate of Hp antibodies in gastrointestinal tract carcinoma group compared with other tumors group was statistically significant difference （P〈0.05）. The other groups compared with the control group,there were no significant difference （P 〉 0.05）. Conclusions It suggests that different antibodies might have some relationship with tumors,but 3 kinds of antibodies have no screening relationship with the diseases of digestive tract,respiratory tract and liver. The positive rates of antibodies in all diseases are lower than 50% ,it has little value for the diagnosis of Hp infection.

关 键 词：幽门螺旋杆菌 蛋白芯片 抗体 

分 类 号：R57[医药卫生—消化系统]