检索规则说明:AND代表“并且”;OR代表“或者”;NOT代表“不包含”;(注意必须大写,运算符两边需空一格)
检 索 范 例 :范例一: (K=图书馆学 OR K=情报学) AND A=范并思 范例二:J=计算机应用与软件 AND (U=C++ OR U=Basic) NOT M=Visual
作 者:陈东梅[1,2] 孟祥颖[2] 申戈[2] 孙冰[2] 丛阳[1] 刘超[1] 王倩[1] 王军良[1] 郝瑞敏[1] 吴世凯[1]
机构地区:[1]安徽医科大学解放军第三0七临床学院,北京100071 [2]解放军第三0七医院放疗科,北京100071
出 处:《中华放射肿瘤学杂志》2017年第2期138-143,共6页Chinese Journal of Radiation Oncology
摘 要:目的探索肺癌脑转移患者海马转移发生率,分析海马转移高危因素,判断海马保护安全性,以协助筛选实施海马保护WBRT人群。方法回顾性收集我院2011-2014年间收治的345例肺癌脑转移患者资料,勾画海马及海马周围5mm边界,Logistics法单因素及多因素分析并确定海马转移的高危因素。Cox模型多因素预后分析。结果颅内总转移灶1621个,发生海马转移16例,海马转移发生率4.6%(16/345),病灶发生率0.99%(16/1621)。海马及其周围5mm发生脑转移者42例,海马区转移发生率12.2%(42/345),病灶发生率2.78%(45/1621)。Logistics单因素、多因素分析均显示脑转移数目与海马转移具有相关性(HR=1.14,P=0.000)。疗后发生颅内进展者139例,海马区转移复发率12.2%(17/139)。Cox分析显示肿瘤分期、基因状态与患者脑转移后0s相关。结论脑转移数目为海马转移高危因素,转移数目多者更易发生海马转移。海马保护WBRT适合于脑转移数目少、肿瘤分期早及存在基因突变或重排肺癌脑转移患者。Objective To investigate the incidence of and high-risk factors for hippocampal metastasis (HM) in patients with brain metastases of lung cancer, to determine the safety of hippocampus- sparing whole brain radiotherapy (HS-WBRT) , and to find out patients eligible for HS-WBRT. Methods A retrospective study was performed on clinical data from 345 patients with brain metastases of lung cancer who were admitted to our hospital from 2011 to 2014. The hippoeampus plus a 5-mm margin was delineated. Univariate and muhivariate logistic analyses were used to identify high-risk factors for hippocampal metastasis. The Cox model was used for multivariate prognostic analysis. Results In the 345 patients, there were 1621 intraeranial metastatic lesions. Sixteen (4. 6%) of the 345 patients and 16(0. 99%) of the 1621 intraeranial metastatic lesions had hippoeampal metastasis ;42( 12. 2%) of the 345 patients and 45 (2. 78% ) of the 1621 intracranial metastatic lesions had metastasis in the hippocampus plus a 5-mm margin. The univariate and multivariate logistic analyses showed that the number of brain metastases was correlated with hippocampal metastasis (HR= 1.14,P= 0.000). In the 139 patients with intracranial progression after treatment, 17 (12. 2%) had hippoeampal metastasis recurrence. The Cox prognostic analysis showed that tumor stage and genetic information were related to the overall survival in patients with brain metastases. Conclusions The number of brain metastases is a high-risk factor for hippocampal metastasis. The lung cancer patients with more brain metastases have a higher incidence of hippoeampal metastasis. HS-WBRT is recommended for lung cancer patients with fewer brain metastases, early-stage disease, and genetic mutations or rearrangement.
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在链接到云南高校图书馆文献保障联盟下载...
云南高校图书馆联盟文献共享服务平台 版权所有©
您的IP:216.73.216.222