四川东北部地区女性高危型人乳头瘤病毒感染情况分析  

An investigation of high risk types of HPV infection among women in Northeast of Sichuan

作　　者：方莉[1,2] 叶红[2] 许媛[1] 陈莹[1] 赵维皎[1] 

机构地区：[1]川北医学院附属医院检验科,四川南充637000 [2]川北医学院医学检验系,四川南充637000

出　　处：《检验医学与临床》2017年第3期352-354,共3页Laboratory Medicine and Clinic

摘　　要：目的分析四川东北部地区女性人群高危型人乳头瘤病毒(HPV)感染情况、基因型分布及患者年龄特征,为预防HPV感染和治疗提供理论依据。方法采用实时荧光定量PCR技术,对川北医学院附属医院6 959例女性筛查者进行高危型HPV亚型检测,并对患者年龄进行分析。结果 6 959例筛查者中共检出HPV阳性患者1 135例,阳性率为16.31%。不同年龄段女性中,30~<40岁和40~<50岁两个年龄段感染率较高,分别为41.76%、42.91%,与20~<30岁年龄段相比,差异均有统计学意义(χ~2=136.2、P<0.05,χ~2=148.9、P<0.05)。所检测的13种HPV亚型中,HPV16、HPV52和HPV58型最常见,分别占24.85%、26.34%和21.59%。结论四川东北地区女性人群高危型HPV感染率高,以HPV16、HPV52和HPV58型最高,患者易感年龄为30~<50岁,临床医师应该重视此类人群的筛查,对降低女性宫颈癌的发生有重要的意义。Objective To analysis the prevalence of high risk types of human papilloma-virus（HPV）infection,age characteristics and genotype distribution in women of Northeast Sichuan,and provide theoretical basis for the prevention and treatment of cervical cancer.Methods Real-time fluorescent quantitative PCR was applied to detect the HPV subtype of high-risk of 6 959 female patients.Meanwhile,the age of patients was analyzed.Results 1 135（16.31%）of 6 959 patients were detected with positive HPV.Furthermore,the positive rate of 30-40（41.76%）and 40-50years age group（42.91%）were high,and which had significant difference with 20-30years age group（χ~2=136.2,P〈0.05,χ~2=148.9,P〈0.05）.Among the 13 kinds of the HPV subtypes,the HPV16（24.85%）,HPV52（26.34%）and HPV58（21.59%）were more familiar.Conclusion The prevalence of HPV infection in women in northeast of Sichuan is high,and the more familiar subtypes are HPV16,HPV58 and HPV52,the age of susceptible high risk HPV subtypes is 30-50years old.

关 键 词：人乳头瘤病毒 高危型 易感年龄 

分 类 号：R737.33[医药卫生—肿瘤]