山橘叶镇咳祛痰平喘作用的实验研究  

Experimental Study on Antitussive,Expectorant and Antiasthmatic Effects of Fortunella Hindsii Leaves

作　　者：邹戬[1] 王薇[1] 李杰[1] Zou Jian Wang Wei Li Jie(Wuhan Hospital of Traditional Chinese Medicine, Wuhan 430014, China)

机构地区：[1]武汉市中医医院,武汉430014

出　　处：《中国药师》2017年第2期256-258,共3页China Pharmacist

基　　金：武汉市中青年医学骨干人才项目(编号:武卫计生通[2015]9号)

摘　　要：目的:研究山橘叶镇咳、祛痰、平喘的作用。方法:采用氨水诱咳法考察山橘叶对小鼠的镇咳作用;采用酚红排泌法考察山橘叶对小鼠的祛痰作用;采用磷酸组胺喷雾法考察山橘叶对豚鼠的平喘作用。结果:山橘叶高、中、低剂量能不同程度地减少氨水诱发的小鼠咳嗽次数,延长小鼠致咳潜伏期(P<0.05或P<0.01);山橘叶高剂量能使小鼠气管段酚红排泌量显著增加(P<0.05);山橘叶高、中剂量能明显延长磷酸组胺喷雾所致豚鼠哮喘的引喘潜伏期(P<0.05或P<0.01)。结论:山橘叶具有显著的抗炎、止咳、祛痰和镇痛作用。Objective： To study the antitussive, expectorant and antiasthetic effects of Fortunella hindsii leaves. Methods： The antitussive effects were observed by the method of ammonia-induced cough in mice, the expectorant effects were observed by the method of phenolsulfonphthalein excretion in mice, and the antiasthmatic effects were observed by the method of histamine phosphate spray in guinea pigs. Results： The leaves of Fortunella hindsii at low, medium and high doses could decrease the cough times and prolong the cough latent period （P 〈 0.05 or P 〈 0.01 ）, high dose could promote the phenol red excretion （P 〈 0.05 ）, and high and medium do- ses could prolong the incubation period of guinea pigs for asthma caused by histamine phosphate （P 〈 0.05 or P 〈 0.01 ）. Conclu- sion： The leaves of FortuneUa hindsii have promising antitussive, expectorant and antiasthmatic effects.

关 键 词：山橘叶具有良好的镇咳 祛痰 平喘作用. 

分 类 号：R285.5[医药卫生—中药学]